Severe sepsis and septic shock can alter the pharmacokinetics of broad-spectrum β-lactams
(meropenem, ceftazidime/cefepime, and piperacillin-tazobactam), resulting in inappropriate …

Objectives: Obesity may alter the pharmacokinetics of β-lactams. The goal of this study was
to evaluate if and why serum concentrations are inadequate when standard β-lactam …

Objective: Obesity and critical illness modify pharmacokinetics of antibiotics, but piperacillin-
tazobactam continuous IV infusion pharmacokinetics has been poorly studied in obese …

The increased prevalence of obesity presents challenges for clinicians aiming to provide
optimised antimicrobial dosing in the intensive care unit. Obesity is likely to exacerbate the …

Objective: Dose optimization of novel β-lactam antibiotics (NBLA) has become necessary
given the increased prevalence of multidrug-resistant infections in intensive care units …

The treatment of infections in critically ill obese and morbidly obese patients is challenging
because of the combined physiological changes that result from obesity and critical illness …

Objectives The objectives of this study were to determine the effects of obesity on unbound
trough concentrations and on the achievement of pharmacokinetic (PK)/pharmacodynamic …

Study Objective To evaluate the steady‐state pharmacokinetic and pharmacodynamic
parameters of piperacillin in morbidly obese, surgical intensive care patients. Design Open …

The highly variable pharmacokinetics of β-lactam antibiotics and β-lactamase inhibitors
poses a significant challenge to clinicians in ensuring appropriate antibiotic doses in …

Abstract Purpose of Review Beta-lactam antibiotics are commonly prescribed in critically ill
patients for a variety of infectious conditions. Our understanding of how critical illness alters …