A long evolution of knowledge of the psychostimulant caffeine led in the 1960s to another
purine natural product, adenosine and its A2A receptor. Adenosine is a short‐lived …

Although significant progress has been made in the past few decades demonstrating that
adenosine modulates a variety of physiological and pathophysiological processes through …

Since the discovery of the biological effects of adenosine, the development of potent and
selective agonists and antagonists of adenosine receptors has been the subject of medicinal …

Adenosine A1 and A2 receptors have been the subject of intense activity in the
pharmaceutical industry. Adenosine agonists, which are almost exclusively derivatives of …

Adenosine is a primordial signaling molecule present in every cell of the human body that
mediates its physiological functions by interacting with 4 subtypes of G-protein-coupled …

Caffeine, the most widely consumed of all psychoactive drugs, is an adenosine receptor
antagonisP3. It is regu-larly ingested by more than half of the adult population in Western …

Background: Adenosine is an endogenous purine nucleoside, which mediates a variety of
important biological processes and diseases, such as vasodilation, inflammation, cancer …

[Frontiers in Bioscience 13, 2391-2399, January 1, 2008] 2391 Adenosine A1-A2A receptor
heteromers: new targets for caffeine in Page 1 [Frontiers in Bioscience 13, 2391-2399, January …

Background: Alzheimer's disease (AD) is the most common form of dementia worldwide,
with approximately 6 million cases reported in America in 2020. The clinical signs of AD …

Adenosine A2B and, much more importantly, adenosine A2A receptors modulate many
physiological and pathological processes in the brain. In this review, the most recent …