Aging hallmarks and progression and age-related diseases: a landscape view of research advancement

R Tenchov, JM Sasso, X Wang… - ACS Chemical …, 2023 - ACS Publications
Aging is a dynamic, time-dependent process that is characterized by a gradual accumulation
of cell damage. Continual functional decline in the intrinsic ability of living organisms to …

Targeting the “hallmarks of aging” to slow aging and treat age-related disease: fact or fiction?

M Keshavarz, K Xie, K Schaaf, D Bano… - Molecular …, 2023 - nature.com
Aging is a major risk factor for a number of chronic diseases, including neurodegenerative
and cerebrovascular disorders. Aging processes have therefore been discussed as potential …

CNS Ageing in health and neurodegenerative disorders

E Kesidou, P Theotokis, O Damianidou… - Journal of Clinical …, 2023 - mdpi.com
The process of ageing is characteristic of multicellular organisms associated with late stages
of the lifecycle and is manifested through a plethora of phenotypes. Its underlying …

Normal aging induces changes in the brain and neurodegeneration progress: review of the structural, biochemical, metabolic, cellular, and molecular changes

J Lee, HJ Kim - Frontiers in aging neuroscience, 2022 - frontiersin.org
Aging is accompanied by many changes in brain and contributes to progressive cognitive
decline. In contrast to pathological changes in brain, normal aging brain changes have …

Association of biological age with health outcomes and its modifiable factors

WS Liu, J You, YJ Ge, BS Wu, Y Zhang, SD Chen… - Aging …, 2023 - Wiley Online Library
Identifying the clinical implications and modifiable and unmodifiable factors of aging
requires the measurement of biological age (BA) and age gap. Leveraging the biomedical …

Mechanisms underlying brain aging under normal and pathological conditions

M Jin, SQ Cai - Neuroscience Bulletin, 2023 - Springer
Aging is a major risk factor for many human diseases, including cognitive impairment, which
affects a large population of the elderly. In the past few decades, our understanding of the …

Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

J Guo, X Huang, L Dou, M Yan, T Shen… - Signal Transduction and …, 2022 - nature.com
Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

Molecular and cellular pathways contributing to brain aging

A Zia, AM Pourbagher-Shahri, T Farkhondeh… - Behavioral and Brain …, 2021 - Springer
Aging is the leading risk factor for several age-associated diseases such as
neurodegenerative diseases. Understanding the biology of aging mechanisms is essential …

Biological aging processes underlying cognitive decline and neurodegenerative disease

MM Gonzales, VR Garbarino, E Pollet… - The Journal of …, 2022 - Am Soc Clin Investig
Alzheimer's disease and related dementias (ADRD) are among the top contributors to
disability and mortality in later life. As with many chronic conditions, aging is the single most …

Molecular and physiological manifestations and measurement of aging in humans

SS Khan, BD Singer, DE Vaughan - Aging cell, 2017 - Wiley Online Library
Biological aging is associated with a reduction in the reparative and regenerative potential
in tissues and organs. This reduction manifests as a decreased physiological reserve in …