Targeting properties of an anti-CD16/anti-CD30 bispecific antibody in an in vivo system
C Renner, I Stehle, FT Lee, C Hall, B Catimel… - Cancer Immunology …, 2001 - Springer
Bispecific antibodies are currently being used in clinical trials in increasing numbers in the
areas of breast cancer, prostate cancer, non-Hodgkin's lymphoma and Hodgkin's lymphoma …
areas of breast cancer, prostate cancer, non-Hodgkin's lymphoma and Hodgkin's lymphoma …
A bispecific diabody that mediates natural killer cell cytotoxicity against xenotransplantated human Hodgkin's tumors
MAE Arndt, J Krauss, SM Kipriyanov… - Blood, The Journal …, 1999 - ashpublications.org
CD16/CD30 bispecific monoclonal antibodies can induce remissions of Hodgkin's disease
refractory to chemo-and radiotherapy. However, the development of human antimouse …
refractory to chemo-and radiotherapy. However, the development of human antimouse …
Anti-CD16/CD30 bispecific antibodies as possible treatment for refractory Hodgkin's disease
F Hartmann, C Renner, W Jung… - Leukemia & …, 1998 - Taylor & Francis
Fifteen patients with refractory Hodgkin's disease were treated in a phase I/II dose escalation
trial with the NK-cell activating bispecific monoclonal antibody HRS-3/A9 which is directed …
trial with the NK-cell activating bispecific monoclonal antibody HRS-3/A9 which is directed …
Human anti-CD30 recombinant antibodies by guided phage antibody selection using cell panning
A Klimka, B Matthey, RC Roovers, S Barth… - British journal of …, 2000 - nature.com
In various clinical studies, Hodgkin's patients have been treated with anti-CD30
immunotherapeutic agents and have shown promising responses. One of the problems that …
immunotherapeutic agents and have shown promising responses. One of the problems that …
Efficient inhibition of human B-cell lymphoma xenografts with an anti-CD20× anti-CD3 bispecific diabody
D Xiong, Y Xu, H Liu, H Peng, X Shao, Z Lai, D Fan… - Cancer letters, 2002 - Elsevier
Bispecific antibodies have been exploited both as cancer immunodiagnostics and as cancer
therapeutics, and have shown promise in several clinical trials in cancer imaging and …
therapeutics, and have shown promise in several clinical trials in cancer imaging and …
Treatment of refractory Hodgkin's disease with an anti-CD16/CD30 bispecific antibody
C Renner, F Hartmann, M Pfreundschuh - Cancer Immunology …, 1997 - Springer
A group of 15 patients with refractory Hodgkin′ s disease were treated in a phase I/II trial
with the natural-killer (NK)-cell-activating bispecific monoclonal antibody HRS-3/A9, which is …
with the natural-killer (NK)-cell-activating bispecific monoclonal antibody HRS-3/A9, which is …
Preclinical development of an anti-CD30/anti-CD16A bispecific tetravalent TandAb antibody for the treatment of Hodgkin lymphoma.
S Knackmuss, U Reusch, C Burkhardt, I Fucek… - 2012 - ascopubs.org
e18532 Background: CD30 is a validated tumor target that is expressed on both Hodgkin's
Lymphoma cells and some activated immune cells. To improve antibody-based therapies …
Lymphoma cells and some activated immune cells. To improve antibody-based therapies …
Performance of CD3xCD19 bispecific monoclonal antibodies in B cell malignancy
IA Haagen - Leukemia & Lymphoma, 1995 - Taylor & Francis
Bispecific monoclonal antibodies, with a dual specificity for tumor associated antigens on
target cells and for surface markers on immune effector cells, have been shown (in vitro) to …
target cells and for surface markers on immune effector cells, have been shown (in vitro) to …
Treatment of refractory Hodgkin's disease with an anti-CD16/CD30 bispecific antibody
F Hartmann, C Renner, W Jung… - Blood, The Journal …, 1997 - ashpublications.org
Fifteen patients with refractory Hodgkin's disease were treated in a phase I/II trial with the
natural killer (NK)-cell–activating bispecific monoclonal antibody HRS-3/A9, which is …
natural killer (NK)-cell–activating bispecific monoclonal antibody HRS-3/A9, which is …
Advances in the study of CD47‐based bispecific antibody in cancer immunotherapy
B Zhang, W Li, D Fan, W Tian, J Zhou, Z Ji… - Immunology, 2022 - Wiley Online Library
Tumour therapy has entered the era of immunotherapy. Monoclonal antibodies (mAb),
immune checkpoint inhibitors, chimeric antigen receptor T‐cell (CAR‐T), cytokine‐induced …
immune checkpoint inhibitors, chimeric antigen receptor T‐cell (CAR‐T), cytokine‐induced …