Background Phenotypic characteristics of patients with eosinophilic and noneosinophilic
asthma are not well characterized in global, real-life severe asthma cohorts. Research …

Objective Severe asthma is associated with substantial personal and economic burden;
maintaining disease control is the key management goal. Increased understanding of …

Background Current biologic therapies target allergic, eosinophilic or type 2 inflammation
phenotypic asthma. However, frequency and degree of overlap among these subtypes is …

Asthma is widely accepted as a complex heterogeneous condition with diverse
pathophysiological mechanisms, clinical presentations, comorbidities, physiological …

Asthma is a heterogeneous disease. The Czech Pneumology and Allergology Societies
commissioned 10 experts to review the literature and create joint national guidelines for …

The term “eosinophilic” asthma (EA) generally refers to the clinical inflammatory phenotype
of asthma wherein a significant number of sputum, airway, and/or blood eosinophils are …

Asthma endotypes are constantly evolving. Currently, there are no universally accepted
criteria to define endotypes. The TH 2-high endotype can have either allergic or nonallergic …

BACKGROUND: Currently, there are no studies of well-characterized severe asthmatics in
Brazil. We aimed to study a population of severe treated asthmatics still uncontrolled to …

Adult-onset eosinophilic asthma is increasingly recognised as a severe and difficult-to-treat
subtype of asthma. In clinical practice, early recognition of patients with this asthma subtype …

Eosinophilic asthma is now recognized as an important subphenotype of asthma based on
the pattern of inflammatory cellular infiltrate in the airway. Eosinophilic asthma can be …