Although the use of cytokine-mobilized peripheral blood stem cells has gained a significant
momentum in clinical transplantation, the mobilization schemes practiced are guided by a …

Interaction of hemopoietic cells with the elements of the underlying bone marrow stroma, the
unique site of their" homing" in adult individuals, is essential for sustained normal …

Although a large body of data on mobilization have yielded valuable clues, the mechanism
(s) dictating egress of stem/progenitor cells during baseline hematopoiesis and after their …

The α4b˜ 1 integrin very late activation antigen-4 (VLA-4) has been implicated to play a role
in the adhesive interactions between hematopoietic progenitor cells (HPC) and bone …

Fibronectin (FN), an extracellular matrix protein, is involved in the adhesion and migration of
hematopoietic cells and has been shown to enhance retroviral gene transfer into primitive …

Selective lodgement or homing of transplanted hemopoietic stem cells in the recipient's
bone marrow (BM) is a critical step in the establishment of long-term hemopoiesis after BM …

The mechanisms by which hematopoietic progenitor cells are normally anchored in stromal
niches and yet can be mobilized by specific growth factors are poorly understood. It is likely …

The laminin receptor integrin α6 chain is ubiquitously expressed in human and mouse
hematopoietic stem and progenitor cells. We have studied its role for homing of stem and …

Alpha4 integrin or VLA4 (CD49d/CD29) is a multitask molecule with wide expression within
and outside the hematopoietic system. Because targeted ablation of α4 integrin leads to …

The hierarchy of cytoadhesion molecules involved in hematopoietic/stem progenitor cell
mobilization has not yet been delineated. Previous studies have suggested an important …