The rate of the tricarboxylic acid cycle is determined by the first step, the citrate synthase
reaction. The rate of this reaction depends on the concentrations of the two substrates …

Previous work has shown that gluconeogenesis from a variety of substrates is stimulated by
oleate. This paper reports data on the effect of oleate on tissue levels of coenzyme A …

1. Citrate synthase (citrate oxaloacetate-lyase (CoA-acetylating), EC 4.1. 3.7) has been
partially purified from beef liver, beef heart and Escherichia coli. The beef heart and beef …

The subcellular distribution of the enzymes involved in oxaloacetate metabolism and certain
related enzymes in the liver of normal fed and starved rats has been studied. A simplified …

In the regulation of ketone body formation the citrate synthase reaction occupies a key
position in determining the metabolic fate of liver acetyl-CoA. As a factor which might shift …

A method is described to calculate the distribution of acetyl-CoA over the citric acid cycle
and ketogenesis during the oxidation of fatty acids in the presence of added malate. 2 …

1. Transient and steady-state changes caused by acetate utilization were studied in
perfused rat heart. The transient period occupied 6min and steady-state changes were …

The rates of O2 consumption during fatty acid oxidation to acetyl‐CoA and to CO2 were
determined for isolated liver cells from starved rats on the basis of measured rates of …

Measurements of citrate formation and endogenous adenine nucleotides in fluorocitrate-
inhibited rat liver mitochondria respiring in the presence of 50 μM (−) palmitoyl carnitine and …

The formation of acetyl-CoA from citrate can be regarded as the first step in the
extramitochondrial synthesis of fatty acidsZ, 2. Acetyl-CoA can also be formed from acetate …