Simple Summary Gene regulation is the major mechanism that allows us to develop from a
single cell to a fully formed adult body containing numerous organs and tissues,> 200 cell …

Protein acetylation is one of the most important posttranslational modifications catalyzed by
acetyltransferases and deacetylases, through the addition and removal of acetyl groups to …

DNA in eukaryotic cells is packaged into chromatin. The main packaging component of
chromatin is the nucleosome, and this is composed of proteins known as histones. Histones …

Cancers are traditionally viewed as a primarily genetic disorder, however this view has
recently been modified by compelling evidence arguing that epigenetic events play …

Histone acetyltransferases (HATs) directly link chromatin modification to gene activation.
Recent structure/function studies provide insights into HAT catalysis and histone binding …

Histone acetyltransferases (HATs) catalyzing N-epsilon-lysine or N-alpha-terminal
acetylation on histone and non-histone substrates are important epigenetic regulators …

Chromatin structure is gaining increasing attention as a potential target in the treatment of
cancer. Relaxation of the chromatin fiber facilitates transcription and is regulated by two …

▪ Abstract Transcriptional regulation in eukaryotes occurs within a chromatin setting and is
strongly influenced by nucleosomal barriers imposed by histone proteins. Among the well …

In recent years it has become widely recognized that histone modification plays a pivotal
role in controlling gene expression and is involved in a wide spectrum of disease regulation …

Gene expression in eukaryotic organisms can be influenced by a host of internal and
external stimuli. The magnitude and duration of the response can often determine the effect …