Abstract A G4C2 hexanucleotide repeat expansion in the C9orf72 gene is the most common
genetic cause of ALS and FTLD (C9-ALS/FTLD) with cytoplasmic TDP-43 inclusions …

A repeat expansion in the non-coding region of C9orf72 gene is the most common mutation
causing frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) …

The cytoplasmic mislocalization and aggregation of TAR DNA-binding protein-43 (TDP-43)
is a common histopathological hallmark of the amyotrophic lateral sclerosis and …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two adult-onset
neurodegenerative diseases that are part of a common disease spectrum due to clinical …

Hexanucleotide repeat expansions in C9orf72 are the most common genetic cause of
amyotrophic lateral sclerosis (C9 ALS). The main hypothesized pathogenic mechanisms are …

TAR DNA-binding protein 43 (TDP-43) inclusions are a pathological hallmark of
frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), including cases …

Aggregation of the RNA‐binding protein TAR DNA‐binding protein 43 (TDP‐43) is the key
neuropathological feature of neurodegenerative diseases, including amyotrophic lateral …

Accumulation and aggregation of TDP-43 is a major pathological hallmark of amyotrophic
lateral sclerosis and frontotemporal dementia. TDP-43 inclusions also characterize patients …

The neuronal microtubule-associated protein tau, MAPT, is central to the pathogenesis of
many dementias. Autosomal-dominant mutations in MAPT cause inherited frontotemporal …

Cytoplasmic aggregation of TDP-43, accompanied by its nuclear clearance, is a key
common pathological hallmark of amyotrophic lateral sclerosis and frontotemporal dementia …