Following traumatic brain injury (TBI), cerebral metabolic dysfunction, characterized by an
elevated cerebral microdialysis (CMD) lactate/pyruvate (LP) ratio, is associated with poor …

Objective: To determine whether persistent metabolic dysfunction in normal-appearing
frontal lobe tissue is correlated with long-term tissue atrophy. Design: Prospective …

Background Traumatic brain injury (TBI) generates regional alterations in cerebral
metabolism, leading to the potential evolution of persistent metabolic dysfunction. In the …

Background Evidence suggests that neurometabolic abnormalities can persist after
traumatic brain injury (TBI) and drive clinical symptoms such as fatigue and cognitive …

Traumatic brain injury (TBI) is a major cause of death and disability, particularly amongst
young people. Current intensive care management of TBI patients is targeted at maintaining …

Traumatic brain injury (TBI) is associated with acute cerebral metabolic crisis (ACMC).
ACMC‐related atrophy appears to be prominent in frontal and temporal lobes following …

After traumatic brain injury (TBI), cerebral metabolism can become deranged, contributing to
secondary injury. Cerebral microdialysis (CMD) allows cerebral metabolism assessment …

Brain trauma is accompanied by regional alterations of brain metabolism, reduction in
metabolic rates and possible energy crisis. We hypothesize that microdialysis markers of …

Following traumatic brain injury (TBI), raised cerebral lactate/pyruvate ratio (LPR) reflects
impaired energy metabolism. Raised LPR correlates with poor outcome and mortality …

Growing evidence suggests that endogenous lactate is an important substrate for neurons.
This study aimed to examine cerebral lactate metabolism and its relationship with brain …