In vitro characterization of new stabilizing albumin nanoparticles as a potential topical drug delivery system in the treatment of corneal neovascularization (CNV)

JM Llabot, IL de Redin, M Agüeros… - Journal of Drug Delivery …, 2019 - Elsevier
The aim of this work was to study the preparation process and the in vitro release of human
serum albumin nanoparticles stabilized by Gantrez® ES-425, which was loaded with …

In vivo effect of bevacizumab-loaded albumin nanoparticles in the treatment of corneal neovascularization

IL de Redín, C Boiero, S Recalde, M Agüeros… - Experimental eye …, 2019 - Elsevier
Corneal neovascularization (CNV) is associated with different ocular pathologies, including
infectious keratitis, trachoma or corneal trauma. Pharmacological treatments based on the …

Human serum albumin nanoparticles for ocular delivery of bevacizumab

IL de Redín, C Boiero, MC Martínez-Ohárriz… - International Journal of …, 2018 - Elsevier
Bevacizumab-loaded nanoparticles (B-NP) were prepared by a desolvation process
followed by freeze-drying, without any chemical, physical or enzymatic cross-linkage …

Albuminated PLGA nanoparticles containing bevacizumab intended for ocular neovascularization treatment

R Varshochian, M Riazi‐Esfahani… - … research part A, 2015 - Wiley Online Library
Bevacizumab, an anti‐VEGF antibody, has demonstrated trustworthy effects in treatment of
retinal and choroidal neovascularization that both are crucial sight threatening conditions …

The protective effect of albumin on bevacizumab activity and stability in PLGA nanoparticles intended for retinal and choroidal neovascularization treatments

R Varshochian, M Jeddi-Tehrani, AR Mahmoudi… - European Journal of …, 2013 - Elsevier
The rapidly growing applications of antibody-based therapeutics requires novel approaches
to develop efficient drug delivery systems in which biodegradable polymeric nanoparticles …

Nanoparticle-mediated corneal neovascularization treatments: Toward new generation of drug delivery systems

H Zhu, J Yu, J Ye, Y Wu, J Pan, Y Li, C Chen… - Chinese Chemical …, 2023 - Elsevier
Corneal neovascularization (CNV) is one of the major factors for vision impairment and
blindness worldwide. The current treatment for CNV focuses primarily on topical eyedrops of …

A SU6668 pure nanoparticle-based eyedrops: toward its high drug Accumulation and Long-time treatment for corneal neovascularization

H Wu, J Ye, M Zhang, L Zhang, S Lin, Q Li, Y Liu… - Journal of …, 2024 - Springer
Corneal neovascularization (CNV) is one of the common blinding factors worldwide, leading
to reduced vision or even blindness. However, current treatments such as surgical …

Effect of nano-encapsulation using human serum albumin on anti-angiogenesis activity of bevacizumab to target corneal neovascularization: Development …

S Narayana, MG Ahmed, A Nasrine - Materials Today: Proceedings, 2022 - Elsevier
Majorly in ocular neovascular diseases or corneal neovascularization, the up-regulation of
vascular endothelial growth factor level has been observed. Bevacizumab is a recombinant …

Ocular implant containing bevacizumab‐loaded chitosan nanoparticles intended for choroidal neovascularization treatment

P Badiee, R Varshochian… - … Research Part A, 2018 - Wiley Online Library
Choroidal neovascularization (CNV) is among the leading causes of blindness worldwide.
Bevacizumab has demonstrated promising effects on CNV treatment; however, frequent …

Pre-clinical safety of topically administered sunitinib-loaded lipid and polymeric nanocarriers targeting corneal neovascularization

LG Souza, AA Sousa-Junior, BAS Cintra… - International Journal of …, 2023 - Elsevier
Three different types of sunitinib-loaded (SUN-loaded) nanocarriers were compared, aiming
at the topical treatment of corneal neovascularization (CNV): polymeric nanospheres (NS) …