Interplay between Colistin Resistance, Virulence and Fitness in Acinetobacter baumannii

GJ Da Silva, S Domingues - Antibiotics, 2017 - mdpi.com
Acinetobacter baumannii is an important opportunistic nosocomial pathogen often resistant
to multiple antibiotics classes. Colistin, an “old” antibiotic, is now considered a last-line …

Colistin Resistance in Acinetobacter baumannii: Molecular Mechanisms and Epidemiology

K Novović, B Jovčić - Antibiotics, 2023 - mdpi.com
Acinetobacter baumannii is recognized as a clinically significant pathogen causing a wide
spectrum of nosocomial infections. Colistin was considered a last-resort antibiotic for the …

Retention of virulence following adaptation to colistin in Acinetobacter baumannii reflects the mechanism of resistance

ME Wand, LJ Bock, LC Bonney… - Journal of Antimicrobial …, 2015 - academic.oup.com
Abstract Objectives Colistin resistance in Acinetobacter baumannii has been associated with
loss of virulence and a negative impact on isolate selection. In this study, exposure of clinical …

The induction and identification of novel Colistin resistance mutations in Acinetobacter baumannii and their implications

N Thi Khanh Nhu, DW Riordan, T Do Hoang Nhu… - Scientific reports, 2016 - nature.com
Acinetobacter baumannii is a significant cause of opportunistic hospital acquired infection
and has been identified as an important emerging infection due to its high levels of …

The Effect of Colistin Resistance-Associated Mutations on the Fitness of Acinetobacter baumannii

X Mu, N Wang, X Li, K Shi, Z Zhou, Y Yu… - Frontiers in …, 2016 - frontiersin.org
Acinetobacter baumannii had emerged as an important nosocomial and opportunistic
pathogen worldwide. To assess the evolution of colistin resistance in A. baumannii and its …

[HTML][HTML] Transcriptomic analysis of colistin-susceptible and colistin-resistant isolates identifies genes associated with colistin resistance in Acinetobacter baumannii

YK Park, JY Lee, KS Ko - Clinical Microbiology and Infection, 2015 - Elsevier
The emergence of colistin-resistant Acinetobacter baumannii is concerning, as colistin is
often regarded as the last option for treating multidrug-resistant (MDR) A. baumannii …

Clinical use of colistin induces cross-resistance to host antimicrobials in Acinetobacter baumannii

BA Napier, EM Burd, SW Satola, SM Cagle, SM Ray… - MBio, 2013 - Am Soc Microbiol
The alarming rise in antibiotic resistance has led to an increase in patient mortality and
health care costs. This problem is compounded by the absence of new antibiotics close to …

New mutations involved in colistin resistance in Acinetobacter baumannii

B Sun, H Liu, Y Jiang, L Shao, S Yang, D Chen - Msphere, 2020 - Am Soc Microbiol
Colistin is used as the “last resort” to treat infections caused by multidrug-resistant
Acinetobacter baumannii, which is at the top of the World Health Organization's list of the …

Biological cost of different mechanisms of colistin resistance and their impact on virulence in Acinetobacter baumannii

A Beceiro, A Moreno, N Fernández… - Antimicrobial agents …, 2014 - Am Soc Microbiol
Two mechanisms of resistance to colistin have been described in Acinetobacter baumannii.
One involves complete loss of lipopolysaccharide (LPS), resulting from mutations in lpxA …

Preferential selection of low-frequency, lipopolysaccharide-modified, colistin-resistant mutants with a combination of antimicrobials in Acinetobacter baumannii

G Kamoshida, N Yamada, T Nakamura… - Microbiology …, 2022 - Am Soc Microbiol
Colistin, which targets lipopolysaccharide (LPS), is used as a last-resort drug against severe
infections caused by drug-resistant Acinetobacter baumannii. However, A. baumannii …