Metagenomic next-generation sequencing to characterize etiologies of non-malarial fever in a cohort living in a high malaria burden area of Uganda
Background Causes of non-malarial fevers in sub-Saharan Africa remain understudied. We
hypothesized that metagenomic next-generation sequencing (mNGS), which allows for …
hypothesized that metagenomic next-generation sequencing (mNGS), which allows for …
[HTML][HTML] Metagenomic next-generation sequencing to characterize potential etiologies of non-malarial fever in a cohort living in a high malaria burden area of Uganda
L Mwakibete, S Takahashi, V Ahyong… - PLOS Global Public …, 2023 - journals.plos.org
Causes of non-malarial fevers in sub-Saharan Africa remain understudied. We hypothesized
that metagenomic next-generation sequencing (mNGS), which allows for broad genomic …
that metagenomic next-generation sequencing (mNGS), which allows for broad genomic …
Next-generation sequencing survey of acute febrile illness in Senegal (2020–2022)
GS Orf, AD Ahouidi, M Mata, C Diedhiou… - Frontiers in …, 2024 - frontiersin.org
Introduction Acute febrile illnesses (AFI) in developing tropical and sub-tropical nations are
challenging to diagnose due to the numerous causes and non-specific symptoms. The …
challenging to diagnose due to the numerous causes and non-specific symptoms. The …
Etiology of fever in Ugandan children: identification of microbial pathogens using metagenomic next-generation sequencing and IDseq, a platform for unbiased …
A Ramesh, S Nakielny, J Hsu, M Kyohere… - Biorxiv, 2018 - biorxiv.org
Background Febrile illness is a major burden in African children, and non-malarial causes of
fever are uncertain. We built and employed IDseq, a cloud-based, open access …
fever are uncertain. We built and employed IDseq, a cloud-based, open access …
[HTML][HTML] Investigating the etiologies of non-malarial febrile illness in Senegal using metagenomic sequencing
ZC Levine, A Sene, W Mkandawire, AB Deme… - Nature …, 2024 - nature.com
The worldwide decline in malaria incidence is revealing the extensive burden of non-
malarial febrile illness (NMFI), which remains poorly understood and difficult to diagnose. To …
malarial febrile illness (NMFI), which remains poorly understood and difficult to diagnose. To …
Discovering disease-causing pathogens in resource-scarce Southeast Asia using a global metagenomic pathogen monitoring system
Understanding the regional pathogen landscape and surveillance of emerging pathogens is
key to mitigating epidemics. Challenges lie in resource-scarce settings, where outbreaks are …
key to mitigating epidemics. Challenges lie in resource-scarce settings, where outbreaks are …
[HTML][HTML] NOMAD: metagenomic characterisation of the viral pathogen composition in outbreaks of non-malaria acute febrile illness cases
BW Kulohoma, I Ng'eno - Open Research Africa, 2022 - openresearchafrica.org
The clinical importance of non-malaria febrile acute illness (NM-AFI) in patients with a
negative parasitological test has become apparent, with the progressive reduction in malaria …
negative parasitological test has become apparent, with the progressive reduction in malaria …
[HTML][HTML] Improving diagnosis of non-malarial fevers in Senegal: Borrelia and the contribution of tick-borne bacteria
ZC Levine, A Sene, W Mkandawire, AB Deme… - medRxiv, 2023 - ncbi.nlm.nih.gov
The worldwide decline in malaria incidence is revealing the extensive burden of non-
malarial febrile illness (NMFI), which remains poorly understood and difficult to diagnose. To …
malarial febrile illness (NMFI), which remains poorly understood and difficult to diagnose. To …
[HTML][HTML] Metagenomic surveillance uncovers diverse and novel viral taxa in febrile patients from Nigeria
Effective infectious disease surveillance in high-risk regions is critical for clinical care and
pandemic preemption; however, few clinical diagnostics are available for the wide range of …
pandemic preemption; however, few clinical diagnostics are available for the wide range of …
Metagenomic sequencing at the epicenter of the Nigeria 2018 Lassa fever outbreak
The 2018 Nigerian Lassa fever season saw the largest ever recorded upsurge of cases,
raising concerns over the emergence of a strain with increased transmission rate. To …
raising concerns over the emergence of a strain with increased transmission rate. To …