Conjugation of polyethylene glycols (PEGs) to proteins or drug delivery nanosystems is a
widely accepted method to increase the therapeutic index of complex nano …

PEGylation technique is currently considered the gold standard approach to provide a long
and safe circulation of drugs. Although this is the accepted dogma, various clinical reports …

The modification of protein and nanoparticle therapeutics with polyethylene glycol (PEG), a
flexible, uncharged, and highly hydrophilic polymer, is a widely adopted approach to reduce …

In this issue of ACS Nano, Chen et al. provide in vitro and in vivo evidence for monoclonal
anti-poly (ethylene glycol)(anti-PEG) antibody-triggered, complement terminal complex …

Highlights•PEGylated nanocarriers are linked to the accelerated blood clearance (ABC)
phenomenon.•The ABC is induced by anti-PEG antibodies and/or complement …

The technique of attaching the polymer polyethylene glycol (PEG), or PEGylation, has
brought more than ten protein drugs into market. The surface conjugation of PEG on proteins …

Polyethylene glycol (PEG) is a common ingredient in nanomedicines and pharmaceuticals.
Recent studies show that approximately 20–70% of humans have anti-PEG antibodies that …

In contrast to the general assumption that polyethyleneglycol (PEG)-conjugated substances
lack immunogenicity and antigenic, it has been reported that they can elicit antibodies …

Circulating antibodies (Ab) that specifically bind polyethylene glycol (PEG), a biocompatible
polymer routinely used in protein and nanoparticle therapeutics, have been associated with …

Since their introduction, poly (ethylene glycol)–phospholipid (PEG–PL) conjugates have
found many applications in design and engineering of nanosized delivery systems for …