Pulmonary senescence is accelerated by unresolved DNA damage response, underpinning
susceptibility to pulmonary fibrosis. Recently it was reported that the SARS-Cov-2 viral …

Cellular senescence due to telomere dysfunction has been hypothesized to play a role in
age-associated diseases including idiopathic pulmonary fibrosis (IPF). It has been …

Idiopathic pulmonary fibrosis (IPF) is a fatal chronic lung disease characterized by
progressive scarring of the lung tissue, leading to respiratory failure. There is no cure for IPF …

Aging is an inevitable and complex natural phenomenon due to the increase in age. Cellular
senescence means a non-proliferative but viable cellular physiological state. It is the basis of …

Idiopathic pulmonary fibrosis (IPF) is a progressive fatal lung disorder with an unknown
etiology and very limited therapeutic options. The incidence and severity of IPF increase with …

Cellular senescence–defined as a stable cell-cycle arrest combined with stereotyped
phenotypic changes–might play a causal role in various lung diseases, including chronic …

Pulmonary fibrosis is a chronic and fatal lung disease that significantly impacts the aging
population globally. To date, anti-fibrotic, immunosuppressive, and other adjunct therapy …

Fibrosing interstitial lung diseases (ILDs) are chronic and ultimately fatal age-related lung
diseases characterized by the progressive and irreversible accumulation of scar tissue in the …

Mutations of human telomerase RNA component (TERC) and telomerase reverse
transcriptase (TERT) are associated with a subset of lung aging diseases, but the …

Cellular senescence represents a state of irreversible cell cycle arrest occurring naturally or
in response to exogenous stressors. Following the initial arrest, progressive phenotypic …