The mechanism of tumor-associated T cell dysfunction remains an unresolved problem of
tumor immunology. Development of T cell defects in tumor-bearing hosts are often …

One of the mechanisms by which tumor cells evade the immune system is the lack of proper
antigen-presenting cells. Improvement in host immunity against tumor cells can be achieved …

Tumor growth is associated with the accumulation of immature myeloid cells (ImC), which in
mice are characterized by the expression of Gr-1 and CD11b markers. These cells suppress …

Activation of T cells is a necessary step in the development of a specific antitumor immune
response. In the present study, we evaluated the ability of Gr-1+ myeloid cells, derived from …

The accumulation of myeloid suppressor cells (MSCs) is associated with immune
suppression in tumor-bearing mice and in cancer patients. The suppressive activity of MSC …

T cell tolerance is a critical element of tumor escape. However, the mechanism of tumor-
associated T cell tolerance remains unresolved. Using an experimental system utilizing the …

In tumor-bearing mice and cancer patients, tumor progression is often associated with
altered hematopoiesis leading to the accumulation of myeloid cells. Extensive studies in …

It is well established that tumor progression is associated with the accumulation of myeloid
suppressive cells, which in mice include Gr-1+ immature myeloid cells and F4/80+ …

An elevated number of Gr-1+ CD11b+ myeloid cells has been described in mice bearing
transplantable tumors, and has been associated with immune suppression. We examined …

Suppression of tumor-specific T cell sensitization is a predominant mechanism of tumor
escape. To identify tumor-induced suppressor cells, we transferred spleen cells from mice …