Gallic acid promotes macrophage phagosome acidification and phagolysosome formation by activating NLRP3/mTOR signaling pathway

Y Cai, J Jiang, C Yue, Z Zhang, W Liu - Journal of Infection and …, 2024 - Elsevier
Introduction Gallic acid (GA) has a good therapeutic effect in bacteriological inhibition and
plays a variety of functions in maintaining the stability of the immune system. The aim of the …

The inhibition of GLUT1-induced glycolysis in macrophage by phloretin participates in the protection during acute lung injury

Y Songyang, W Li, W Li, J Yang, TB Song - International …, 2022 - Elsevier
The increased level of glycolysis in macrophage aggravates lipopolysaccharide (LPS)-
induced acute lung injury (ALI). Glucose transporter 1 (GLUT1) serves as a ubiquitously …

Effects of gallic acid on signaling kinases in murine macrophages and immune modulation against Brucella abortus 544 infection in mice

AWB Reyes, LT Arayan, HT Hop, TXN Huy, SH Vu… - Microbial …, 2018 - Elsevier
In this study, we investigated the effects of gallic acid (GA) in intracellular signaling within
murine macrophages and its contribution to host immunity during Brucella infection. In vitro …

In vivo fluid accumulation-inhibitory, anticolonization and anti-inflammatory and in vitro biofilm-inhibitory activities of methyl gallate isolated from Terminalia chebula …

PK Bag, N Roy, S Acharyya, DR Saha, H Koley… - Microbial …, 2019 - Elsevier
Acute Vibrio cholerae infection triggers significant inflammatory response and immense fluid
secretion in the intestine. In the present study, methyl gallate (MG) isolated from Terminalia …

[HTML][HTML] Galacto-oligosaccharides alleviate lung inflammation by inhibiting NLRP3 inflammasome activation in vivo and in vitro

Y Cai, MS Gilbert, WJJ Gerrits, G Folkerts… - Journal of Advanced …, 2022 - Elsevier
Introduction The lack of effective anti-inflammatory therapies for pneumonia represents a
challenge for identifying new alternatives. Non-digestible galacto-oligosaccharides (GOS) …

D-mannose acts as a V-ATPase inhibitor to suppress inflammatory cytokines generation and bacterial killing in macrophage

M Zhao, N Chen, Y Guo, N Wu, B Cao, B Zhan, Y Li… - Molecular …, 2023 - Elsevier
Abstract Vacuolar-type H+-ATPase (V-ATPase) critically controls phagosome acidification to
promote pathogen digestion and clearance in macrophage. However, the specific subunits …

[HTML][HTML] Lysophosphatidylcholine enhances bactericidal activity by promoting phagosome maturation via the activation of the NF-κB pathway during salmonella …

HJ Lee, WG Hong, Y Woo, JH Ahn, HJ Ko, H Kim… - Molecules and cells, 2020 - Elsevier
Salmonella enterica serovar Typhimurium (S. Typhimurium) is a facultative intracellular
pathogen that causes salmonellosis and mortality worldwide. S. Typhimurium infects …

[HTML][HTML] Gallic acid reduces the effect of LPS on apoptosis and inhibits the formation of neutrophil extracellular traps

GV Haute, E Caberlon, E Squizani, FC de Mesquita… - Toxicology In Vitro, 2015 - Elsevier
Apoptosis and NETosis of neutrophils are two major mechanisms of programmed cell death
that differ in their morphological characteristics and effects on the immune system. Apoptosis …

[HTML][HTML] Lactobacillus reuteri Ameliorates Lipopolysaccharide-Induced Acute Lung Injury by Modulating the Gut Microbiota in Mice

J Shen, S Wang, Y Huang, Z Wu, S Han, H Xia, H Chen… - Nutrients, 2023 - mdpi.com
Acute lung injury (ALI) causes lung inflammation and edema as well as resulting in gut
microbiota disorder. Probiotics, however, can improve the gut microbiota composition and …

Lysophosphatidylcholine increases neutrophil bactericidal activity by enhancement of azurophil granule-phagosome fusion via Glycine· GlyRα2/TRPM2/p38 MAPK …

CW Hong, TK Kim, HY Ham, JS Nam… - The Journal of …, 2010 - journals.aai.org
Neutrophils are the first-line defense against microbes. Enhancing the microbicidal activity of
neutrophils could complement direct antimicrobial therapy for controlling intractable …