Gallic acid promotes macrophage phagosome acidification and phagolysosome formation by activating NLRP3/mTOR signaling pathway
Y Cai, J Jiang, C Yue, Z Zhang, W Liu - Journal of Infection and …, 2024 - Elsevier
Introduction Gallic acid (GA) has a good therapeutic effect in bacteriological inhibition and
plays a variety of functions in maintaining the stability of the immune system. The aim of the …
plays a variety of functions in maintaining the stability of the immune system. The aim of the …
The inhibition of GLUT1-induced glycolysis in macrophage by phloretin participates in the protection during acute lung injury
Y Songyang, W Li, W Li, J Yang, TB Song - International …, 2022 - Elsevier
The increased level of glycolysis in macrophage aggravates lipopolysaccharide (LPS)-
induced acute lung injury (ALI). Glucose transporter 1 (GLUT1) serves as a ubiquitously …
induced acute lung injury (ALI). Glucose transporter 1 (GLUT1) serves as a ubiquitously …
Effects of gallic acid on signaling kinases in murine macrophages and immune modulation against Brucella abortus 544 infection in mice
In this study, we investigated the effects of gallic acid (GA) in intracellular signaling within
murine macrophages and its contribution to host immunity during Brucella infection. In vitro …
murine macrophages and its contribution to host immunity during Brucella infection. In vitro …
In vivo fluid accumulation-inhibitory, anticolonization and anti-inflammatory and in vitro biofilm-inhibitory activities of methyl gallate isolated from Terminalia chebula …
PK Bag, N Roy, S Acharyya, DR Saha, H Koley… - Microbial …, 2019 - Elsevier
Acute Vibrio cholerae infection triggers significant inflammatory response and immense fluid
secretion in the intestine. In the present study, methyl gallate (MG) isolated from Terminalia …
secretion in the intestine. In the present study, methyl gallate (MG) isolated from Terminalia …
[HTML][HTML] Galacto-oligosaccharides alleviate lung inflammation by inhibiting NLRP3 inflammasome activation in vivo and in vitro
Y Cai, MS Gilbert, WJJ Gerrits, G Folkerts… - Journal of Advanced …, 2022 - Elsevier
Introduction The lack of effective anti-inflammatory therapies for pneumonia represents a
challenge for identifying new alternatives. Non-digestible galacto-oligosaccharides (GOS) …
challenge for identifying new alternatives. Non-digestible galacto-oligosaccharides (GOS) …
D-mannose acts as a V-ATPase inhibitor to suppress inflammatory cytokines generation and bacterial killing in macrophage
M Zhao, N Chen, Y Guo, N Wu, B Cao, B Zhan, Y Li… - Molecular …, 2023 - Elsevier
Abstract Vacuolar-type H+-ATPase (V-ATPase) critically controls phagosome acidification to
promote pathogen digestion and clearance in macrophage. However, the specific subunits …
promote pathogen digestion and clearance in macrophage. However, the specific subunits …
[HTML][HTML] Lysophosphatidylcholine enhances bactericidal activity by promoting phagosome maturation via the activation of the NF-κB pathway during salmonella …
HJ Lee, WG Hong, Y Woo, JH Ahn, HJ Ko, H Kim… - Molecules and cells, 2020 - Elsevier
Salmonella enterica serovar Typhimurium (S. Typhimurium) is a facultative intracellular
pathogen that causes salmonellosis and mortality worldwide. S. Typhimurium infects …
pathogen that causes salmonellosis and mortality worldwide. S. Typhimurium infects …
[HTML][HTML] Gallic acid reduces the effect of LPS on apoptosis and inhibits the formation of neutrophil extracellular traps
GV Haute, E Caberlon, E Squizani, FC de Mesquita… - Toxicology In Vitro, 2015 - Elsevier
Apoptosis and NETosis of neutrophils are two major mechanisms of programmed cell death
that differ in their morphological characteristics and effects on the immune system. Apoptosis …
that differ in their morphological characteristics and effects on the immune system. Apoptosis …
[HTML][HTML] Lactobacillus reuteri Ameliorates Lipopolysaccharide-Induced Acute Lung Injury by Modulating the Gut Microbiota in Mice
J Shen, S Wang, Y Huang, Z Wu, S Han, H Xia, H Chen… - Nutrients, 2023 - mdpi.com
Acute lung injury (ALI) causes lung inflammation and edema as well as resulting in gut
microbiota disorder. Probiotics, however, can improve the gut microbiota composition and …
microbiota disorder. Probiotics, however, can improve the gut microbiota composition and …
Lysophosphatidylcholine increases neutrophil bactericidal activity by enhancement of azurophil granule-phagosome fusion via Glycine· GlyRα2/TRPM2/p38 MAPK …
CW Hong, TK Kim, HY Ham, JS Nam… - The Journal of …, 2010 - journals.aai.org
Neutrophils are the first-line defense against microbes. Enhancing the microbicidal activity of
neutrophils could complement direct antimicrobial therapy for controlling intractable …
neutrophils could complement direct antimicrobial therapy for controlling intractable …