[HTML][HTML] PLGA-quercetin nano-formulation inhibits cancer progression via mitochondrial dependent caspase-3, 7 and independent FoxO1 activation with concomitant …

N Yadav, AK Tripathi, A Parveen, S Parveen… - Pharmaceutics, 2022 - mdpi.com
Quercetin is one of the most important plant flavanols, having several pharmacological and
biological uses. Quercetin (Q) is an extremely hydrophobic phytochemical and has poor …

[HTML][HTML] Quercetin nanoparticles display antitumor activity via proliferation inhibition and apoptosis induction in liver cancer cells

KW Ren, YH Li, G Wu, JZ Ren… - International …, 2017 - spandidos-publications.com
Quercetin is a potent cancer therapeutic agent and dietary antioxidant present in fruit and
vegetables. Quercetin prevents tumor proliferation by inducing cell cycle arrest and is a well …

Nano-chemotherapeutic efficacy of (−)-epigallocatechin 3-gallate mediating apoptosis in A549 cells: Involvement of reactive oxygen species mediated Nrf2 …

B Velavan, T Divya, A Sureshkumar… - … and biophysical research …, 2018 - Elsevier
Chemotherapeutic drugs exert systemic toxicity in lung cancer cells and therefore novel
treatment strategies are warranted. Epigallocatechin 3-gallate (EGCG), though possessing …

Quercetin induces MGMT+ glioblastoma cells apoptosis via dual inhibition of Wnt3a/β-Catenin and Akt/NF-κB signaling pathways

W Wang, X Yuan, J Mu, Y Zou, L Xu, J Chen, X Zhu… - Phytomedicine, 2023 - Elsevier
Background Surgical resection combined with radiotherapy and chemotherapy remains a
common clinical treatment for glioblastoma multiforme (GBM). However, the therapeutic …

Quercetin nanoparticles induced autophagy and apoptosis through AKT/ERK/Caspase-3 signaling pathway in human neuroglioma cells: In vitro and in vivo

M Lou, L Zhang, P Ji, F Feng, J Liu, C Yang, B Li… - Biomedicine & …, 2016 - Elsevier
Neuroglioma is a complex neuroglial tumor involving dysregulation of many biological
pathways at multiple levels. Quercetin is a potent cancer therapeutic agent presented in fruit …

CS-PEG decorated PLGA nano-prototype for delivery of bioactive compounds: A novel approach for induction of apoptosis in HepG2 cell line

AA Abd-Rabou, HH Ahmed - Advances in medical sciences, 2017 - Elsevier
Purpose Polymer-based nanoparticles are used as vectors for cancer drug delivery. The
bioactive compounds (quercetin, ellagic acid and gallic acid) are well known to be not only …

Quercetin against MCF7 and CAL51 breast cancer cell lines: apoptosis, gene expression and cytotoxicity of nano-quercetin

HA Mohammed, GM Sulaiman, SS Anwar… - …, 2021 - Taylor & Francis
Aims: To evaluate the anti breast-cancer activity, biocompatibility and toxicity of poly (d, l)-
lactic-co-glycolic acid (PLGA)-encapsulated quercetin nanoparticles (Q-PLGA-NPs) …

Phloretin loaded chitosan nanoparticles augments the pH-dependent mitochondrial-mediated intrinsic apoptosis in human oral cancer cells

AVA Mariadoss, R Vinayagam, V Senthilkumar… - International journal of …, 2019 - Elsevier
The aim of the present investigation is to explore the innovative platform for the synthesis of
plant-based nanoparticles, which contain biocompatible and biodegradable carrier of …

[HTML][HTML] Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kγ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling …

HW Zhang, JJ Hu, RQ Fu, X Liu, YH Zhang, J Li, L Liu… - Scientific reports, 2018 - nature.com
Anticancer activities of flavonoids derived from Tephroseris kirilowii (Turcz.) Holub. were
evaluated in human cancer cells. We isolated and identified, for the first time, eight …

Augmentation of anti-proliferative efficacy of quercetin encapsulated chitosan nanoparticles by induction of cell death via mitochondrial membrane permeabilization in …

P Das, S Ghosh, V Ashashainy, B Nayak - International Journal of …, 2023 - Elsevier
Quercetin (QCT), an antioxidant plant flavonoid, is known to impart prominent anti-cancer
properties. However, its clinical application as a potential drug is hindered owing to its …