Vaccination, being able to prevent millions of cases of infectious diseases around the world
every year, is the most effective medical intervention ever introduced. However …

The number of people that are 65 years old or older has been increasing due to the
improvement in medicine and public health. However, this trend is not accompanied by an …

Average life expectancy is continuously rising in all developed countries, leading to an ever-
increasing elderly population. Of the many functions of the body affected by the complex …

The immune system of the elderly is particularly susceptible to infectious diseases and
displays reduced response to vaccination. The current vaccines, designed for young and …

Vaccines are powerful public health tools that have been of tremendous benefit in protecting
vulnerable populations worldwide from many pathogens. However, vaccine-preventable …

The article by Goronzy et al.( 6) addresses the paradox of an age-dependent decline in
immune responses while autoimmune diseases increase in incidence. The authors …

Immunosenescence increases the risk and severity of diseases in elderly individuals and
leads to impaired vaccine-induced immunity. With aging of the global population and the …

The increased susceptibility of the elderly to infection presents a major challenge to public
health services. An aging immune system is well documented as the cause of increased …

Highlights•Aging is associated with a decline in immune function termed 'immune
senescence'.•Effective influenza vaccines need to be developed for better protection the …

One of the most appreciated consequences of immunosenescence is an impaired response
to vaccines with advanced age. While most studies report impaired antibody responses in …