In recent years, a number of bioorthogonal reactions have been developed, exemplified by
click chemistry, that enable the efficient formation of a specific product, even within a highly …

The rapid advancement of bio-orthogonal click chemistry in the past decade has enabled
the study and precise manipulation of biological processes within living organisms. The …

The term “click chemistry” defines a powerful set of chemical reactions that are rapid,
selective, and high‐yielding. These reactions, some of which are less than 10 years old …

Specific and highly efficient fluorescent labeling techniques for biomolecules, especially for
proteins, are required for the quantitative analyses of bio-phenomena and for subsequent …

Despite advances in genetic and proteomic techniques, a complete portrait of the proteome
and its complement of dynamic interactions and modifications remains a lofty, and as of yet …

The recent discovery of bioorthogonal click chemistry has created a new field in chemical
biology in which biomolecules that are not directly encoded in the genome can be monitored …

The selective chemical modification of biological molecules drives a good portion of modern
drug development and fundamental biological research. While a few early examples of …

Chemistry, traditionally being the science of synthesis and structural manipulations of
molecules, has gradually undertaken the more challenging task of biology-oriented …

Highlights•Popular bioorthogonal reagents and reactions are highlighted.•Methods to tune
bioorthogonal functional group reactivity and stability are described.•Strategies to achieve …

Over the years, there have been remarkable efforts in the development of selective protein
labeling strategies. In this review, we deliver a comprehensive overview of the currently …