Management of cancer is challenging due to non-targeting and high side effect issues. Drug
repurposing is an innovative method for employing medications for other disease therapy in …

Objectives Exploring the use of statins as anticancer agents and exploiting different drug
delivery systems in targeting these molecules to cancerous sites. Literature review was …

Statins are drugs traditionally used to lower cholesterol levels in blood. At concentrations
100-to 500-fold higher than those needed for reaching cholesterol lowering activity, they …

Statins, typically used to reduce lipid levels, have been rediscovered for exhibiting
anticancer activities. Among them, especially simvastatin may influence the proliferation …

Abstract Folate conjugated Simvastatin loaded Solid lipid nanoparticles (SIM-SLNs) were
constructed after the preformulation studies such as Differential calorie metry (DSC), Fourier …

Numerous and different types of cancers possess the dysregulation of the mevalonate
pathway as a common feature. Statins, traditionally applied in cardiovascular diseases to …

Simvastatin (SMV) is an antihyperlipidemic agent that has been investigated as a possible
anti-cancer agent. An obstacle to malignant tumor therapy using drugs is the delivery of …

Background Statins induces cell cycle arrest, apoptosis, reduction of angiogenic factors,
inhibition of the endothelial growth factor, impairing tissue adhesion and attenuation of the …

During past few years, development of methods for physical encapsulation of drugs in
biocompatible materials in mild conditions for poorly water-soluble hydrophobic drugs which …

A dual pH-and time-dependent polymeric coated capsule was developed to achieve the site
specificity of simvastatin (SIM) release in the colon. To improve the SIM solubility, soluplus …