OBJECTIVE: The aim of the study was to consider statistical and methodological issues
affecting the results of meta-analysis of genetic association studies for pertinent gene …

Meta-analyses of population-based molecular association studies have become
increasingly common over the last 10 years, but little attention has been paid to …

The object of this review is to help readers to understand meta-analysis of genetic
association study. Genetic association studies are a powerful approach to identify …

Genetic association studies have the potential to advance our understanding of genotype-
phenotype relationships, especially for common, complex diseases where other …

Background To evaluate gene–disease associations, genetic epidemiologists collect
information on the disease risk in subjects with different genotypes (for a bi-allelic …

Meta-analysis is a useful tool to increase the statistical power to detect gene–disease
associations by combining results from the original and subsequent replication studies …

Emerging technologies are allowing researchers to study hundreds of thousands of genetic
variants simultaneously as risk factors for common complex diseases. Both theoretical …

Non-replication and inconsistency had been common features in the search for common
variants of candidate genes affecting the risk of complex diseases. They may continue to …

The number of published genetic association studies (GASs) is increasing tremendously
due to the availability of mapped single-nucleotide polymorphisms (SNPs) and advances in …

Meta-analysis offers the opportunity to combine evidence from retrospectively accumulated
or prospectively generated data. Meta-analyses may provide summary estimates and can …