BACKGROUND The majority of patients with pancreatic cancer who undergo curative
resection experience rapid disease recurrence. In previous small studies, high expression of …

ABSTRACT DNA mismatch repair gene MutL homolog-1 (MLH1) has divergent effects in
many cancers, however, its impact on the metastasis of pancreatic ductal adenocarcinoma …

Abstract Background/Aims: Defective DNA mismatch repair (MMR) in pancreatic cancer,
reported in up to 13% of sporadic pancreatic cancers, may predict a good prognosis. To …

Purpose DNA mismatch repair (MMR) is critical in maintaining genomic stability and may
modulate the cellular response to gemcitabine. We hypothesized that genetic variations in …

To investigate the relationship between the hypermethylation statuses of the mismatch
repair genes (hMLH1 and hMSH2) promoters and explore the correlation between it and the …

Background Microsatellite instability (MSI) has emerged as a predictive biomarker for
immune checkpoint inhibitor therapy. Cancer heterogeneity represents a potential obstacle …

PURPOSE: Loss of function or expression of the mismatch repair protein MLH1 and the
tumor suppressor protein p53 have been implicated in acquired resistance to anticancer …

Purpose. DNA mismatch repair (MMR) maintains genomic stability and mediates cellular
response to DNA damage. We aim to demonstrate whether MMR genetic variants affect …

The DNA repair machinery plays a key role in maintaining genomic stability by preventing
the emergence of mutations. Furthermore, the− 93G> A polymorphism in the MLH1 gene …

Objective To describe the clinical, pathological and genomic characteristics of pancreatic
cancer with DNA mismatch repair deficiency (MMRD) and proficiency (MMRP). Design We …