The intestinal epithelium serves as a dynamic barrier to the environment and integrates a
variety of signals, including those from metabolites, commensal microbiota, immune …

Adult somatic stem cells facilitate tissue homeostasis throughout the life of the organism. The
mechanisms controlling stem cell activity are under intense scrutiny, with the aims of …

Regenerative processes that maintain the function of the gastrointestinal (GI) epithelium are
critical for health and survival of multicellular organisms. In insects and vertebrates, intestinal …

Stem cells have essential functions in the development and maintenance of our organs.
Improper regulation of adult stem cells and tissue homeostasis can result in cancers and …

As a barrier epithelium, the intestinal epithelium has to coordinate physiological functions
like digestion and nutrient resorption with the control of commensal bacteria and the …

Although intestinal homeostasis is maintained by intestinal stem cells (ISCs), regeneration is
impaired upon aging. Here, we first uncover changes in intestinal architecture, cell number …

The intestine is one of the organs that relies on stem cell function for maintaining tissue
homeostasis. Recent findings on intestinal aging show that intestinal architecture, such as …

Ageing results in loss of tissue homeostasis across taxa. In the intestine of Drosophila
melanogaster, ageing is correlated with an increase in intestinal stem cell (ISC) proliferation …

In many tissues, stem cell (SC) proliferation is dynamically adjusted to regenerative needs.
How SCs adapt their metabolism to meet the demands of proliferation and how changes in …

Regenerative processes are critical to maintain tissue homeostasis in high-turnover tissues.
At the same time, proliferation of stem and progenitor cells has to be carefully controlled to …