Dopamine (DA) regulates emotional and motivational behavior through the mesolimbic
dopaminergic pathway. Changes in DA mesolimbic neurotransmission have been found to …

Dopamine (DA) regulates emotional and motivational behavior through the mesolimbic
dopaminergic pathway. Changes in DA signaling in mesolimbic neurotransmission are …

Highlights•Obesity and addiction result in diminished D2 receptor availability in striatum.•D2
receptors control compulsive eating.•DREADDs and optogenetics have revealed a key role …

Dopamine (DA) signaling controls many physiological functions ranging from locomotion to
hormone secretion, and plays a critical role in addiction. DA elevation, for instance in …

To benefit from opportunities and cope with challenges in the environment, animals must
adapt their behavior to acquire rewards and to avoid punishments. Maladaptive changes in …

Dopamine (DA) D2 receptors expressed in DA neurons (D2 autoreceptors) exert a negative
feedback regulation that reduces DA neuron firing, DA synthesis and DA release. As D2 …

Altered mesolimbic dopamine signaling has been widely implicated in addictive behavior.
For the most part, this work has focused on dopamine within the striatum, but there is …

Striatal dopamine receptor D1-expressing neurons have been classically associated with
positive reinforcement and reward, whereas D2 neurons are associated with negative …

Dopamine (DA) receptors play critical roles in a wide range of behaviours, including sensory
processing, motor function, reward and arousal. As such, aberrant DA signalling is …

Background and hypothesis Based on neurochemical and genetic evidence, we suggest
that both prevention and treatment of multiple addictions, such as dependence to alcohol …