Metabolic pathways, enzymes, and metabolites: Opportunities in cancer therapy

R Kumar, A Mishra, P Gautam, Z Feroz… - Cancers, 2022 - mdpi.com
Simple Summary Deregulated cellular metabolism is one of the major hallmarks of cancer.
Cancer cells orchestrate abnormal metabolic reprogramming to satisfy high energy …

Dysregulated metabolism in cancer

A Isa - Biomedical Research and Therapy, 2022 - biomedpress.org
Metabolism describes the cellular bioenergetic pathways that provide energy and
macromolecules for protein, lipid, and nucleic acid syntheses. In cancer, malignant cells …

Recent advances in cancer metabolism: a technological perspective

YP Kang, NP Ward, GM DeNicola - Experimental & molecular medicine, 2018 - nature.com
Cancer cells are highly dependent on metabolic pathways to sustain both their proliferation
and adaption to harsh microenvironments. Thus, understanding the metabolic …

[HTML][HTML] Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies

LM Phan, SCJ Yeung, MH Lee - Cancer biology & medicine, 2014 - ncbi.nlm.nih.gov
Cancer cells are well documented to rewire their metabolism and energy production
networks to support and enable rapid proliferation, continuous growth, survival in harsh …

Metabolic tricks of cancer cells

K Hönigova, J Navratil, B Peltanova… - … et Biophysica Acta (BBA …, 2022 - Elsevier
One of the characteristics of cancer cells important for tumorigenesis is their metabolic
plasticity. Indeed, in various stress conditions, cancer cells can reshape their metabolic …

Cancer Metabolism

MA Reid, SM Sanderson, JW Locasale - Abeloff's Clinical Oncology, 2020 - Elsevier
Cancer cells have different nutritional requirements from their normal counterparts, and
rewire their metabolism to support uncontrolled proliferation. In recent years, extensive study …

Metabolic reprogramming in cancer: Mechanisms and therapeutics

S Nong, X Han, Y Xiang, Y Qian, Y Wei, T Zhang… - MedComm, 2023 - Wiley Online Library
Cancer cells characterized by uncontrolled growth and proliferation require altered
metabolic processes to maintain this characteristic. Metabolic reprogramming is a process …

[PDF][PDF] Therapeutic targeting of cancer cell metabolism: role of metabolic enzymes, oncogenes and tumor suppressor genes

R Majeed, A Hamid, Y Qurishi, AK Qazi… - J Cancer Sci …, 2012 - academia.edu
Cancer cells compared to their normal counterparts reveal different metabolic needs and
this differential requirement of metabolic intermediates and their subsequent consequences …

Metabolic classification and intervention opportunities for tumor energy dysfunction

E Monferrer, I Vieco-Martí, A López-Carrasco, F Fariñas… - Metabolites, 2021 - mdpi.com
A comprehensive view of cell metabolism provides a new vision of cancer, conceptualized
as tissue with cellular-altered metabolism and energetic dysfunction, which can shed light …

Fundamentals of cancer metabolism

RJ DeBerardinis, NS Chandel - Science advances, 2016 - science.org
Tumors reprogram pathways of nutrient acquisition and metabolism to meet the
bioenergetic, biosynthetic, and redox demands of malignant cells. These reprogrammed …