Progressive resistance exercise training (PRT) is the most effective known intervention for
combating aging skeletal muscle atrophy. However, the hypertrophic response to PRT is …

Evidence from clinical trials and observational studies suggests that both progressive
resistance exercise training (PRT) and metformin delay a variety of age-related morbidities …

Administration of metformin increases healthspan and lifespan in model systems, and
evidence from clinical trials and observational studies suggests that metformin delays a …

Muscle inflammation and fibrosis underlie disuse‐related complications and may contribute
to impaired muscle recovery in aging. Cellular senescence is an emerging link between …

Metformin and exercise independently improve insulin sensitivity and decrease the risk of
diabetes. Metformin was also recently proposed as a potential therapy to slow aging …

Introduction Although resistance type exercise training (RT) effectively increases muscle
mass and strength in older individuals, it remains unclear whether gains in muscle mass and …

Aging is associated with low‐grade inflammation. The benefits of regular exercise for the
elderly are well established, whereas less is known about the impact of low‐intensity …

Background and Purpose: In older people with type 2 diabetes mellitus (T2DM), the effects
of aging and T2DM may compromise the function of skeletal muscle, deteriorate metabolic …

Loss of muscle mass and strength with aging, also termed sarcopenia, results in a loss of
mobility and independence. Exercise, particularly resistance training, has proven to be …

Age-related sarcopenia inhibits mobility, increasing the risk for developing many diseases,
including diabetes, arthritis, osteoporosis, and heart disease. Tissue plasticity, or the ability …