Nerve‐Sparing Gynecologic Surgery Enabled by A Near‐Infrared Nerve‐Specific Fluorophore Using Existing Clinical Fluorescence Imaging Systems

CW Barth, SZH Rizvi, AM Masillati, S Chakraborty… - Small, 2023 - Wiley Online Library
Patients undergoing gynecological procedures suffer from lasting side effects due to
intraoperative nerve damage. Small, delicate nerves with complex and nonuniform …

Clinically Translatable Formulation Strategies for Systemic Administration of Nerve‐Specific Probes

CW Barth, VM Shah, LG Wang, AL Antaris… - Advanced …, 2021 - Wiley Online Library
Nerves are extremely difficult to identify and are often accidently damaged during surgery,
leaving patients with lasting pain and numbness. Herein, a novel near‐infrared (NIR) nerve …

Improved intraoperative visualization of nerves through a myelin-binding fluorophore and dual-mode laparoscopic imaging

VE Cotero, SY Kimm, TM Siclovan, R Zhang, EM Kim… - PloS one, 2015 - journals.plos.org
The ability to visualize and spare nerves during surgery is critical for avoiding chronic
morbidity, pain, and loss of function. Visualization of such critical anatomic structures is even …

[HTML][HTML] First demonstration of a novel nerve-targeting fluorophore in a cohort of ex vivo human tissues

KA Hebert, L Bateman, D Parker… - Proceedings of SPIE …, 2023 - ncbi.nlm.nih.gov
Iatrogenic nerve injury is a common complication across all surgical specialties. Better nerve
visualization and identification during surgery will improve outcomes and reduce nerve …

Near-infrared nerve-binding fluorophores for buried nerve tissue imaging

LG Wang, CW Barth, CH Kitts, MD Mebrat… - Science translational …, 2020 - science.org
Nerve-binding fluorophores with near-infrared (NIR; 650 to 900 nm) emission could reduce
iatrogenic nerve injury rates by providing surgeons precise, real-time visualization of the …

Structure-activity relationship of nerve-highlighting fluorophores

SL Gibbs, Y Xie, HL Goodwill, KA Nasr, Y Ashitate… - PloS one, 2013 - journals.plos.org
Nerve damage is a major morbidity associated with numerous surgical interventions. Yet,
nerve visualization continues to challenge even the most experienced surgeons. A nerve …

Investigation of oxazine and rhodamine derivatives as peripheral nerve tissue targeting contrast agent for in vivo fluorescence imaging

LG Wang, CW Barth, JR Combs… - … , and Applications V, 2019 - spiedigitallibrary.org
Accidental nerve transection or injury is a significant morbidity associated with many surgical
interventions, resulting in persistent postsurgical numbness, chronic pain, and/or paralysis …

Fluorescence imaging of nerves during surgery

EM Walsh, D Cole, KE Tipirneni, KI Bland… - Annals of …, 2019 - journals.lww.com
Objective: This review details the agents for fluorescence-guided nerve imaging in both
preclinical and clinical use to identify factors important in selecting nerve-specific fluorescent …

Improving precision surgery: A review of current intraoperative nerve tissue fluorescence imaging

LG Wang, SL Gibbs - Current opinion in chemical biology, 2023 - Elsevier
Iatrogenic nerve injury represents one of the most feared surgical complications and
remains a major morbidity across many surgical specialties. Currently, no clinically …

Real-time near-infrared fluorescence guided surgery in gynecologic oncology: a review of the current state of the art

HJM Handgraaf, FPR Verbeek, QRJG Tummers… - Gynecologic …, 2014 - Elsevier
Near-infrared (NIR) fluorescence imaging has emerged as a promising complimentary
technique for intraoperative visualization of tumor tissue, lymph nodes and vital structures. In …