Nerve‐Sparing Gynecologic Surgery Enabled by A Near‐Infrared Nerve‐Specific Fluorophore Using Existing Clinical Fluorescence Imaging Systems
Patients undergoing gynecological procedures suffer from lasting side effects due to
intraoperative nerve damage. Small, delicate nerves with complex and nonuniform …
intraoperative nerve damage. Small, delicate nerves with complex and nonuniform …
Clinically Translatable Formulation Strategies for Systemic Administration of Nerve‐Specific Probes
Nerves are extremely difficult to identify and are often accidently damaged during surgery,
leaving patients with lasting pain and numbness. Herein, a novel near‐infrared (NIR) nerve …
leaving patients with lasting pain and numbness. Herein, a novel near‐infrared (NIR) nerve …
Improved intraoperative visualization of nerves through a myelin-binding fluorophore and dual-mode laparoscopic imaging
VE Cotero, SY Kimm, TM Siclovan, R Zhang, EM Kim… - PloS one, 2015 - journals.plos.org
The ability to visualize and spare nerves during surgery is critical for avoiding chronic
morbidity, pain, and loss of function. Visualization of such critical anatomic structures is even …
morbidity, pain, and loss of function. Visualization of such critical anatomic structures is even …
[HTML][HTML] First demonstration of a novel nerve-targeting fluorophore in a cohort of ex vivo human tissues
KA Hebert, L Bateman, D Parker… - Proceedings of SPIE …, 2023 - ncbi.nlm.nih.gov
Iatrogenic nerve injury is a common complication across all surgical specialties. Better nerve
visualization and identification during surgery will improve outcomes and reduce nerve …
visualization and identification during surgery will improve outcomes and reduce nerve …
Near-infrared nerve-binding fluorophores for buried nerve tissue imaging
Nerve-binding fluorophores with near-infrared (NIR; 650 to 900 nm) emission could reduce
iatrogenic nerve injury rates by providing surgeons precise, real-time visualization of the …
iatrogenic nerve injury rates by providing surgeons precise, real-time visualization of the …
Structure-activity relationship of nerve-highlighting fluorophores
Nerve damage is a major morbidity associated with numerous surgical interventions. Yet,
nerve visualization continues to challenge even the most experienced surgeons. A nerve …
nerve visualization continues to challenge even the most experienced surgeons. A nerve …
Investigation of oxazine and rhodamine derivatives as peripheral nerve tissue targeting contrast agent for in vivo fluorescence imaging
LG Wang, CW Barth, JR Combs… - … , and Applications V, 2019 - spiedigitallibrary.org
Accidental nerve transection or injury is a significant morbidity associated with many surgical
interventions, resulting in persistent postsurgical numbness, chronic pain, and/or paralysis …
interventions, resulting in persistent postsurgical numbness, chronic pain, and/or paralysis …
Fluorescence imaging of nerves during surgery
EM Walsh, D Cole, KE Tipirneni, KI Bland… - Annals of …, 2019 - journals.lww.com
Objective: This review details the agents for fluorescence-guided nerve imaging in both
preclinical and clinical use to identify factors important in selecting nerve-specific fluorescent …
preclinical and clinical use to identify factors important in selecting nerve-specific fluorescent …
Improving precision surgery: A review of current intraoperative nerve tissue fluorescence imaging
LG Wang, SL Gibbs - Current opinion in chemical biology, 2023 - Elsevier
Iatrogenic nerve injury represents one of the most feared surgical complications and
remains a major morbidity across many surgical specialties. Currently, no clinically …
remains a major morbidity across many surgical specialties. Currently, no clinically …
Real-time near-infrared fluorescence guided surgery in gynecologic oncology: a review of the current state of the art
HJM Handgraaf, FPR Verbeek, QRJG Tummers… - Gynecologic …, 2014 - Elsevier
Near-infrared (NIR) fluorescence imaging has emerged as a promising complimentary
technique for intraoperative visualization of tumor tissue, lymph nodes and vital structures. In …
technique for intraoperative visualization of tumor tissue, lymph nodes and vital structures. In …