Microfluidic tools for enhanced characterization of therapeutic stem cells and prediction of their potential antimicrobial secretome
P Marrazzo, V Pizzuti, S Zia, A Sargenti, D Gazzola… - Antibiotics, 2021 - mdpi.com
Antibiotic resistance is creating enormous attention on the development of new antibiotic-
free therapy strategies for bacterial diseases. Mesenchymal stromal stem cells (MSCs) are …
free therapy strategies for bacterial diseases. Mesenchymal stromal stem cells (MSCs) are …
Antimicrobial activity of mesenchymal stem cells: current status and new perspectives of antimicrobial peptide-based therapies
While mesenchymal stem cells (MSCs)-based therapy appears to be promising, there are
concerns regarding possible side effects related to the unwanted suppression of …
concerns regarding possible side effects related to the unwanted suppression of …
Multiomics characterization of mesenchymal stromal cells cultured in monolayer and as aggregates
G Doron, ME Klontzas, A Mantalaris… - Biotechnology and …, 2020 - Wiley Online Library
Mesenchymal stromal cells (MSCs) have failed to consistently demonstrate their therapeutic
efficacy in clinical trials, due in part to variability in culture conditions used for their …
efficacy in clinical trials, due in part to variability in culture conditions used for their …
The mesenchymal stromal cell secretome impairs methicillin-resistant Staphylococcus aureus biofilms via cysteine protease activity in the equine model
C Marx, S Gardner, RM Harman… - Stem cells …, 2020 - academic.oup.com
Mesenchymal stromal cells (MSCs) from various species, such as humans, mice, and
horses, were recently found to effectively inhibit the growth of various bacteria associated …
horses, were recently found to effectively inhibit the growth of various bacteria associated …
Exploring the roles of MSCs in infections: Focus on bacterial diseases
Despite human healthcare advances, some microorganisms continuously react evolving
new survival strategies, choosing between a commensal fitness and a pathogenic attitude …
new survival strategies, choosing between a commensal fitness and a pathogenic attitude …
Isolation, cultivation, and characterization of human mesenchymal stem cells
D Mushahary, A Spittler, C Kasper, V Weber… - Cytometry Part …, 2018 - Wiley Online Library
Mesenchymal stem cells (MSC) exhibit a high self‐renewal capacity, multilineage
differentiation potential and immunomodulatory properties. This set of exceptional features …
differentiation potential and immunomodulatory properties. This set of exceptional features …
Biological considerations in scaling up therapeutic cell manufacturing
Cell therapeutics—using cells as living drugs—have made advances in many areas of
medicine. One of the most clinically studied cell-based therapy products is mesenchymal …
medicine. One of the most clinically studied cell-based therapy products is mesenchymal …
Concise review: microfluidic technology platforms: poised to accelerate development and translation of stem cell-derived therapies
DM Titmarsh, H Chen, NR Glass… - Stem cells …, 2014 - academic.oup.com
Stem cells are a powerful resource for producing a variety of cell types with utility in clinically
associated applications, including preclinical drug screening and development, disease and …
associated applications, including preclinical drug screening and development, disease and …
Mechanism and potential of extracellular vesicles derived from mesenchymal stem cells for the treatment of infectious diseases
J You, Z Fu, L Zou - Frontiers in Microbiology, 2021 - frontiersin.org
Extracellular vesicles (EVs) are nano-sized membrane vesicles secreted by cells. EVs serve
as a mediator for cell-to-cell communication by regulating the exchange of genetic materials …
as a mediator for cell-to-cell communication by regulating the exchange of genetic materials …
Mesenchymal stromal cell secretome: influencing therapeutic potential by cellular pre-conditioning
JR Ferreira, GQ Teixeira, SG Santos… - Frontiers in …, 2018 - frontiersin.org
Mesenchymal stromal cells (MSCs) are self-renewing, culture-expandable adult stem cells
that have been isolated from a variety of tissues, and possess multipotent differentiation …
that have been isolated from a variety of tissues, and possess multipotent differentiation …