[HTML][HTML] Salsolinol: an unintelligible and double-faced molecule—lessons learned from in vivo and in vitro experiments

M Kurnik-Łucka, P Panula, A Bugajski, K Gil - Neurotoxicity Research, 2018 - Springer
Abstract Salsolinol (1-methyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline) is a
tetrahydroisoquinoline derivative whose presence in humans was first detected in the urine …

The mechanism of action of salsolinol in brain: implications in Parkinson's disease

SM Voon, KY Ng, SM Chye, APK Ling… - CNS & Neurological …, 2020 - ingentaconnect.com
1-Methyl-1, 2, 3, 4-tetrahydroisoquinoline-6, 7-diol, commonly known as salsolinol, is a
compound derived from dopamine. It was first discovered in 1973 and has gained attention …

[HTML][HTML] Salsolinol, an endogenous compound triggers a two-phase opposing action in the central nervous system

E Możdżeń, M Kajta, A Wąsik, T Lenda… - Neurotoxicity …, 2015 - Springer
Abstract Salsolinol (1-methyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline), an
endogenous compound present in the brain, was suspected of participation in the …

Biosynthesis of salsolinol, a tetrahydroisoquinoline alkaloid, in healthy subjects

P Dostert, M Strolin Benedetti, V Bellotti… - Journal of Neural …, 1990 - Springer
The R enantiomer of salsolinol was detected in the urine of two out of six healthy subjects,
whereas 1, 2-dehydrosalsolinol was present in the urine of all the subjects.(S)-salsolinol …

R-and S-salsolinol are not increased in cerebrospinal fluid of Parkinsonian patients

T Müller, SS Baum, P Häussermann, H Przuntek… - Journal of the …, 1999 - Elsevier
Various investigators address an augmented synthesis of tetrahydroisoquinolines, such as
salsolinol (SAL), or an increased N-methylation of these compounds as putative …

N-Methyl-(R)salsolinol as a dopaminergic neurotoxin: From an animal model to an early marker of Parkinson's disease

M Naoi, W Maruyama, P Dostert… - Advances in Research on …, 1997 - Springer
Summary A dopamine-derived 1 (R), 2 (N)-dimethyl-6, 7-dihydroxy-1, 2, 3, 4-
tetrahydrosioquinoline [N-methyl-(R) salsolinol] was found to occur enantio-selectively in …

Plasma levels of R-and S-salsolinol are not increased in" de-novo" Parkinsonian patients

T Müller, S Sällström Baum, P Häussermann… - Journal of neural …, 1998 - Springer
An augmented synthesis of tetrahydroisoquinolines, such as salsolinol (SAL) or an
increased N-methylation of these compounds has been addressed by various investigators …

Dopamine-derived endogenous N-methyl-(R)-salsolinol: its role in Parkinson's disease

M Naoi, W Maruyama, Y Akao, H Yi - Neurotoxicology and teratology, 2002 - Elsevier
A dopamine-derived alkaloid, N-methyl-(R)-salsolinol [NM (R) Sal], enantioselectively
occurs in human brains and accumulates in the nigrostriatal system. It increases in the …

Analysis of salsolinol and salsoline in biological samples using deuterium-labelled internal standards and gas chromatography—mass spectrometry

B Sjöquist, E Magnuson - … of Chromatography B: Biomedical Sciences and …, 1980 - Elsevier
Salsolinol and salsoline were labelled with deuterium using an acidic exchange reaction in
2 HCl 2 H 2 O. Two deuterium atoms were incorporated in both compounds. The …

[HTML][HTML] Salsolinol—neurotoxic or Neuroprotective?

M Kurnik-Łucka, G Latacz, A Martyniak, A Bugajski… - Neurotoxicity …, 2020 - Springer
Abstract Salsolinol (6, 7-dihydroxy-1-methyl-1, 2, 3, 4-tetrahydroisoquinoline), widely
available in many edibles, is considered to alter the function of dopaminergic neurons in the …