Background: Cross-sectional imaging studies offer valuable pathological insights into the
neurodegenerative changes of amyotrophic lateral sclerosis. However, clinical trials urgently …

In ALS, advanced magnetic resonance imaging (MRI) techniques are increasingly used to
investigate the underlying pathology. In this study, the technique of voxel‐based …

ObjectiveAdvanced neuroimaging techniques may offer the potential to monitor disease
progression in amyotrophic lateral sclerosis (ALS), a neurodegenerative, multisystem …

Amyotrophic lateral sclerosis is a progressive neurodegenerative disease that affects upper
and lower motor neurons. Observational and intervention studies can be tracked using …

In patients with ALS, conventional MR imaging is frequently noninformative, and its use has
been restricted to excluding other conditions that can mimic ALS. Conversely, the extensive …

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease for which a precise
cause has not yet been identified. Standard CT or MRI evaluation does not demonstrate …

We investigated 17 patients with sporadic amyotrophic lateral sclerosis (ALS) using voxel-
based morphometry (VBM) and voxel-based analysis of diffusion tensor images (DTI) at …

Purpose To establish the relationship between ALS histopathology and quantitative MRI
metrics. Materials and Methods ALS patients (N= 8) in advanced stages of the disease were …

Purpose The lifetime risk of developing amyotrophic lateral sclerosis (ALS) increases in the
elderly, and greater age at symptom onset has been identified as a negative prognostic …

Amyotrophic lateral sclerosis (ALS) is now recognised to be a heterogeneous
neurodegenerative syndrome of the motor system and its frontotemporal cortical …