Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus

MY Cheng, CM Bullock, C Li, AG Lee, JC Bermak… - Nature, 2002 - nature.com
The suprachiasmatic nucleus (SCN) controls the circadian rhythm of physiological and
behavioural processes in mammals. Here we show that prokineticin 2 (PK2), a cysteine-rich …

Prokineticin receptor 2 (Prokr2) is essential for the regulation of circadian behavior by the suprachiasmatic nuclei

HM Prosser, A Bradley, JE Chesham… - Proceedings of the …, 2007 - National Acad Sciences
The suprachiasmatic nucleus (SCN), the brain's principal circadian pacemaker, coordinates
adaptive daily cycles of behavior and physiology, including the rhythm of sleep and …

Regulation of prokineticin 2 expression by light and the circadian clock

MY Cheng, EL Bittman, S Hattar, QY Zhou - BMC neuroscience, 2005 - Springer
Background The suprachiasmatic nucleus (SCN) contains the master circadian clock that
regulates daily rhythms of many physiological and behavioural processes in mammals …

Prokineticin 2 and circadian clock output

QY Zhou, MY Cheng - The FEBS journal, 2005 - Wiley Online Library
Circadian timing from the suprachiasmatic nucleus (SCN) is a critical component of sleep
regulation. Animal lesion and genetic studies have indicated an essential interaction …

Attenuated circadian rhythms in mice lacking the prokineticin 2 gene

JD Li, WP Hu, L Boehmer, MY Cheng… - Journal of …, 2006 - Soc Neuroscience
Circadian clocks drive daily rhythms in virtually all organisms. In mammals, the
suprachiasmatic nucleus (SCN) is recognized as the master clock that synchronizes central …

Altered circadian and homeostatic sleep regulation in prokineticin 2-deficient mice

WP Hu, JD Li, C Zhang, L Boehmer, JM Siegel… - Sleep, 2007 - academic.oup.com
Abstract Study Objectives: Sleep is regulated by circadian and homeostatic processes.
Recent studies with mutant mice have indicated that circadian-related genes regulate sleep …

Efferent projections of prokineticin 2 expressing neurons in the mouse suprachiasmatic nucleus

C Zhang, KK Truong, QY Zhou - PloS one, 2009 - journals.plos.org
The suprachiasmatic nucleus (SCN) in the hypothalamus is the predominant circadian clock
in mammals. To function as a pacemaker, the intrinsic timing signal from the SCN must be …

A role for cardiotrophin-like cytokine in the circadian control of mammalian locomotor activity

S Kraves, CJ Weitz - Nature neuroscience, 2006 - nature.com
The suprachiasmatic nucleus (SCN) drives circadian rhythms of locomotor behavior by
releasing factors that act on receptor sites near the third ventricle. Here we show that …

Sleep states alter activity of suprachiasmatic nucleus neurons

T Deboer, MJ Vansteensel, L Détári, JH Meijer - Nature neuroscience, 2003 - nature.com
The timing of sleep and wakefulness in mammals is governed by a sleep homeostatic
process and by the circadian clock of the suprachiasmatic nucleus (SCN), which has a …

Targeted microlesions reveal novel organization of the hamster suprachiasmatic nucleus

LJ Kriegsfeld, J LeSauter, R Silver - Journal of Neuroscience, 2004 - Soc Neuroscience
The role of the suprachiasmatic nuclei (SCN) in generating circadian rhythms in physiology
and behavior is well established. Recent evidence based on clock gene expression …