Immune cells regulate a hypertonic microenvironment in the skin; however, the biological
advantage of increased skin Na+ concentrations is unknown. We found that Na+ …

During tissue inflammation, immune cells infiltrate the interstitial space of target organs,
where they sense and adapt to local environmental stimuli. Such stimuli include not only …

The skin can serve as an interstitial Na+ reservoir. Local tissue Na+ accumulation increases
with age, inflammation and infection. This increased local Na+ availability favors pro …

The Western diet is rich in salt, which poses various health risks. A high-salt diet (HSD) can
stimulate immunity through the nuclear factor of activated T cells 5 (Nfat5)–signaling …

The incidence of allergic diseases has increased over the past 50 years, likely due to
environmental factors. However, the nature of these factors and the mode of action by which …

The Western diet is rich in salt, and a high salt diet (HSD) is suspected to be a risk factor for
cardiovascular diseases. It is now widely accepted that an experimental HSD can stimulate …

A high intake of dietary salt (NaCl) has been implicated in the development of hypertension,
chronic inflammation, and autoimmune diseases. We have recently shown that salt has a …

Recently, studies have emerged suggesting that the skin plays a role as major Na+ reservoir
via regulation of the content of glycosaminoglycans and osmotic gradients. We investigated …

High dietary sodium intake triggers increased blood pressure (BP). Animal studies show that
dietary salt loading results in dermal Na+ accumulation and lymphangiogenesis mediated …

Besides their role in immune system host defense, there is growing evidence that
macrophages may also be important regulators of salt homeostasis and blood pressure by a …