Interactions of inhaled liposome with macrophages and neutrophils determine particle biofate and anti-inflammatory effect in acute lung inflammation
Since most current studies have focused on exploring how phagocyte internalization of drug-
loaded nanovesicles by macrophages would affect the function and therapeutic effects of …
loaded nanovesicles by macrophages would affect the function and therapeutic effects of …
Interplay between mucus mobility and alveolar macrophage targeting of surface-modified liposomes
KB Japiassu, F Fay, A Marengo… - Journal of controlled …, 2022 - Elsevier
Alveolar macrophages play a crucial role in the initiation and resolution of the immune
response in the lungs. Pro-inflammatory M1 alveolar macrophages are an interesting target …
response in the lungs. Pro-inflammatory M1 alveolar macrophages are an interesting target …
Lung targeted liposomes for treating ARDS
SA Raviv, M Alyan, E Egorov, A Zano… - Journal of controlled …, 2022 - Elsevier
Abstract Acute Respiratory Distress Syndrome (ARDS), associated with Covid-19 infections,
is characterized by diffuse lung damage, inflammation and alveolar collapse that impairs …
is characterized by diffuse lung damage, inflammation and alveolar collapse that impairs …
Hybrid biomimetic nanovesicles to drive high lung biodistribution and prevent cytokine storm for ARDS treatment
Q Qiao, X Liu, K Cui, X Li, T Tian, Y Yu, B Niu, L Kong… - ACS …, 2022 - ACS Publications
Acute respiratory distress syndrome (ARDS) has been a life threat for patients in ICUs. Vast
efforts have been devoted, while no medication has proved viable, which may be ascribed to …
efforts have been devoted, while no medication has proved viable, which may be ascribed to …
Neutrophil membrane-coated therapeutic liposomes for targeted treatment in acute lung injury
Z Huang, H Wang, J Long, Z Lu, C Chun, X Li - International Journal of …, 2022 - Elsevier
Acute lung injury (ALI) is one of the most common comorbidities associated with sepsis and
can lead to acute respiratory distress syndrome. Intense inflammatory response due to …
can lead to acute respiratory distress syndrome. Intense inflammatory response due to …
Remote Co-loading of amphipathic acid drugs in neutrophil nanovesicles infilled with cholesterol mitigates lung bacterial infection and inflammation
Lung bacterial infections could result in acute lung inflammation/injury (ALI) that propagates
to its severe form, acute respiratory distress syndrome (ADRS) leading to the death. The …
to its severe form, acute respiratory distress syndrome (ADRS) leading to the death. The …
Exploring the influence of inhaled liposome membrane fluidity on its interaction with pulmonary physiological barriers
J Zhao, J Su, L Qin, X Zhang, S Mao - Biomaterials Science, 2020 - pubs.rsc.org
Liposomes are promising vectors for pulmonary drug delivery, and have been used in
marketed inhalation products. Membrane fluidity is an important property of liposomes …
marketed inhalation products. Membrane fluidity is an important property of liposomes …
Mechanisms by which liposomes improve inhaled drug delivery for alveolar diseases
LT Ferguson, X Ma, JW Myerson, J Wu… - Advanced …, 2023 - Wiley Online Library
Diseases of the pulmonary alveolus, such as pulmonary fibrosis, are leading causes of
morbidity and mortality, but exceedingly few drugs are developed for them. A major reason …
morbidity and mortality, but exceedingly few drugs are developed for them. A major reason …
[HTML][HTML] Liposomes-Human phagocytes interplay in whole blood: effect of liposome design
M Giambelluca, E Markova, C Louet, B Steinkjer… - … , Biology and Medicine, 2023 - Elsevier
Nanomedicine holds immense potential for therapeutic manipulation of phagocytic immune
cells. However, in vitro studies often fail to accurately translate to the complex in vivo …
cells. However, in vitro studies often fail to accurately translate to the complex in vivo …
Neutrophils enable local and non‐invasive liposome delivery to inflamed skeletal muscle and ischemic heart
Uncontrolled inflammation is a major pathological factor underlying a range of diseases
including autoimmune conditions, cardiovascular disease, and cancer. Improving localized …
including autoimmune conditions, cardiovascular disease, and cancer. Improving localized …