Modeling neurodegenerative diseases with cerebral organoids and other three-dimensional culture systems: Focus on Alzheimer's disease
Many neurodegenerative diseases (NDs) such as Alzheimer's disease, Parkinson's disease,
frontotemporal dementia, amyotrophic lateral sclerosis and Huntington's disease, are …
frontotemporal dementia, amyotrophic lateral sclerosis and Huntington's disease, are …
Three-dimensional modeling of human neurodegeneration: brain organoids coming of age
K Grenier, J Kao, P Diamandis - Molecular psychiatry, 2020 - nature.com
The prevalence of dementia and other neurodegenerative diseases is rapidly increasing in
aging nations. These relentless and progressive diseases remain largely without disease …
aging nations. These relentless and progressive diseases remain largely without disease …
Modelling neurodegenerative disease using brain organoids
S Wray - Seminars in Cell & Developmental Biology, 2021 - Elsevier
Abstract Neurodegenerative Diseases such as Alzheimer's Disease represent a major
public health challenge, with no disease modifying therapies available. The availability of …
public health challenge, with no disease modifying therapies available. The availability of …
Dissecting Alzheimer's disease pathogenesis in human 2D and 3D models
G Cenini, M Hebisch, V Iefremova, LJ Flitsch… - Molecular and Cellular …, 2021 - Elsevier
The incidence of Alzheimer's disease is increasing with the aging population, and it has
become one of the main health concerns of modern society. The dissection of the underlying …
become one of the main health concerns of modern society. The dissection of the underlying …
Modelling neurodegenerative diseases with 3D brain organoids
Y Chang, J Kim, H Park, H Choi, J Kim - Biological Reviews, 2020 - Wiley Online Library
Neurodegenerative diseases are incurable and debilitating conditions characterized by the
deterioration of brain function. Most brain disease models rely on human post‐mortem brain …
deterioration of brain function. Most brain disease models rely on human post‐mortem brain …
The use of pluripotent stem cell-derived organoids to study extracellular matrix development during neural degeneration
The mechanism that causes the Alzheimer's disease (AD) pathologies, including amyloid
plaque, neurofibrillary tangles, and neuron death, is not well understood due to the lack of …
plaque, neurofibrillary tangles, and neuron death, is not well understood due to the lack of …
Current progress of cerebral organoids for modeling Alzheimer's disease origins and mechanisms
S Sreenivasamurthy, M Laul, N Zhao… - Bioengineering & …, 2023 - Wiley Online Library
Alzheimer's disease (AD) is a progressive, neurodegenerative disease that has emerged as
a leading risk factor for dementia associated with increasing age. Two‐dimensional (2D) cell …
a leading risk factor for dementia associated with increasing age. Two‐dimensional (2D) cell …
Modeling amyloid beta and tau pathology in human cerebral organoids
C Gonzalez, E Armijo, J Bravo-Alegria… - Molecular …, 2018 - nature.com
The typical abnormalities observed in the brain of Alzheimer's disease (AD) patients include
synaptic alterations, neuronal death, brain inflammation, and the accumulation of protein …
synaptic alterations, neuronal death, brain inflammation, and the accumulation of protein …
Modeling Alzheimer's disease using human brain organoids
K Karmirian, M Holubiec, L Goto-Silva… - … Disease: Methods and …, 2022 - Springer
Alzheimer's disease (AD) is the primary cause of dementia, to date. The urgent need to
understand the biological and biochemical processes related to this condition, as well as the …
understand the biological and biochemical processes related to this condition, as well as the …
Beyond animal models: revolutionizing neurodegenerative disease modeling using 3D in vitro organoids, microfluidic chips, and bioprinting
Neurodegenerative diseases (NDs) are characterized by uncontrolled loss of neuronal cells
leading to a progressive deterioration of brain functions. The transition rate of numerous …
leading to a progressive deterioration of brain functions. The transition rate of numerous …