Modeling neurodegenerative diseases with cerebral organoids and other three-dimensional culture systems: Focus on Alzheimer's disease

L Venkataraman, SR Fair, CA McElroy… - Stem cell reviews and …, 2020 - Springer
Many neurodegenerative diseases (NDs) such as Alzheimer's disease, Parkinson's disease,
frontotemporal dementia, amyotrophic lateral sclerosis and Huntington's disease, are …

Three-dimensional modeling of human neurodegeneration: brain organoids coming of age

K Grenier, J Kao, P Diamandis - Molecular psychiatry, 2020 - nature.com
The prevalence of dementia and other neurodegenerative diseases is rapidly increasing in
aging nations. These relentless and progressive diseases remain largely without disease …

Modelling neurodegenerative disease using brain organoids

S Wray - Seminars in Cell & Developmental Biology, 2021 - Elsevier
Abstract Neurodegenerative Diseases such as Alzheimer's Disease represent a major
public health challenge, with no disease modifying therapies available. The availability of …

Dissecting Alzheimer's disease pathogenesis in human 2D and 3D models

G Cenini, M Hebisch, V Iefremova, LJ Flitsch… - Molecular and Cellular …, 2021 - Elsevier
The incidence of Alzheimer's disease is increasing with the aging population, and it has
become one of the main health concerns of modern society. The dissection of the underlying …

Modelling neurodegenerative diseases with 3D brain organoids

Y Chang, J Kim, H Park, H Choi, J Kim - Biological Reviews, 2020 - Wiley Online Library
Neurodegenerative diseases are incurable and debilitating conditions characterized by the
deterioration of brain function. Most brain disease models rely on human post‐mortem brain …

The use of pluripotent stem cell-derived organoids to study extracellular matrix development during neural degeneration

Y Yan, J Bejoy, M Marzano, Y Li - Cells, 2019 - mdpi.com
The mechanism that causes the Alzheimer's disease (AD) pathologies, including amyloid
plaque, neurofibrillary tangles, and neuron death, is not well understood due to the lack of …

Current progress of cerebral organoids for modeling Alzheimer's disease origins and mechanisms

S Sreenivasamurthy, M Laul, N Zhao… - Bioengineering & …, 2023 - Wiley Online Library
Alzheimer's disease (AD) is a progressive, neurodegenerative disease that has emerged as
a leading risk factor for dementia associated with increasing age. Two‐dimensional (2D) cell …

Modeling amyloid beta and tau pathology in human cerebral organoids

C Gonzalez, E Armijo, J Bravo-Alegria… - Molecular …, 2018 - nature.com
The typical abnormalities observed in the brain of Alzheimer's disease (AD) patients include
synaptic alterations, neuronal death, brain inflammation, and the accumulation of protein …

Modeling Alzheimer's disease using human brain organoids

K Karmirian, M Holubiec, L Goto-Silva… - … Disease: Methods and …, 2022 - Springer
Alzheimer's disease (AD) is the primary cause of dementia, to date. The urgent need to
understand the biological and biochemical processes related to this condition, as well as the …

Beyond animal models: revolutionizing neurodegenerative disease modeling using 3D in vitro organoids, microfluidic chips, and bioprinting

P Teli, V Kale, A Vaidya - Cell and Tissue Research, 2023 - Springer
Neurodegenerative diseases (NDs) are characterized by uncontrolled loss of neuronal cells
leading to a progressive deterioration of brain functions. The transition rate of numerous …