Adenosine is a potent modulator of neuronal activity throughout the nervous system.
Previous evidence suggests that adenosine presynaptically inhibits synaptic transmission …

Adenosine is released in the brain in significant quantities in response to increased cellular
activity. Adenosine has been shown either to decrease synaptic transmission or to produce …

Adenosine is a potent inhibitory modulator of synaptic transmission in the CNS, but its role in
normal physiological function is unclear. In the present experiments, we have found …

1. The role of adenosine receptors in reducing calcium currents (ICa) and in triggering
presynaptic inhibition was studied using whole‐cell patch‐clamp techniques to record ICa …

The mechanisms underlying the depressant effect of adenosine on excitatory synaptic
transmission were studied in rat hippocampus in vitro. The relative contribution of direct …

Extracellular and intracellular recordings from CA1 pyramidal neurones of rats in vitro were
used to study the effects of endogenous and exogenously applied adenosine. The …

In rat hippocampal slices, stimulus-evoked field potentials and the concominant decrease of
the extracellular concentration of free Ca ions [Ca 2+] o were measured with combined …

We have utilized the favorable signal-to-noise ratios provided by whole-cell recording,
combined with variance analysis, to determine the pre-or postsynaptic actions of a variety of …

The effects of the adenosine A1 receptor agonist, N6-cyclopentyladenosine (CPA), on both
the increase in intracellular free Ca2+ concentration ([Ca2+] i) and on the release of …

The effect of adenosine on paired synaptic responses was characterized in the CA1 region
of the rat hippocampus in vitro. Adenosine increased the degree of synaptic facilitation at a …