[HTML][HTML] Estimating the heritability of SARS-CoV-2 susceptibility and COVID-19 severity
KLR Brown, V Ramlall, M Zietz, U Gisladottir… - Nature …, 2024 - nature.com
SARS-CoV-2 has infected over 340 million people, prompting therapeutic research. While
genetic studies can highlight potential drug targets, understanding the heritability of SARS …
genetic studies can highlight potential drug targets, understanding the heritability of SARS …
[HTML][HTML] Expanded COVID-19 phenotype definitions reveal distinct patterns of genetic association and protective effects
Multiple COVID-19 genome-wide association studies (GWASs) have identified reproducible
genetic associations indicating that there is a genetic component to susceptibility and …
genetic associations indicating that there is a genetic component to susceptibility and …
[HTML][HTML] Common genetic variation in humans impacts in vitro susceptibility to SARS-CoV-2 infection
K Dobrindt, DA Hoagland, C Seah, B Kassim… - Stem Cell Reports, 2021 - cell.com
The host response to SARS-CoV-2, the etiologic agent of the COVID-19 pandemic,
demonstrates significant interindividual variability. In addition to showing more disease in …
demonstrates significant interindividual variability. In addition to showing more disease in …
Trans-ethnic analysis reveals genetic and non-genetic associations with COVID-19 susceptibility and severity
JF Shelton, AJ Shastri, C Ye, CH Weldon… - MedRxiv, 2020 - medrxiv.org
COVID-19 presents with a wide range of severity, from asymptomatic in some individuals to
fatal in others. Based on a study of over one million 23andMe research participants, we …
fatal in others. Based on a study of over one million 23andMe research participants, we …
[HTML][HTML] Human genetic factors associated with susceptibility to SARS-CoV-2 infection and COVID-19 disease severity
C Anastassopoulou, Z Gkizarioti, GP Patrinos… - Human genomics, 2020 - Springer
Background The emergence of the novel coronavirus in Wuhan, Hubei Province, China, in
December 2019 marked the synchronization of the world to a peculiar clock that is counting …
December 2019 marked the synchronization of the world to a peculiar clock that is counting …
[HTML][HTML] Trans-ancestry analysis reveals genetic and nongenetic associations with COVID-19 susceptibility and severity
JF Shelton, AJ Shastri, C Ye, CH Weldon… - Nature Genetics, 2021 - nature.com
COVID-19 presents with a wide range of severity, from asymptomatic in some individuals to
fatal in others. Based on a study of 1,051,032 23andMe research participants, we report …
fatal in others. Based on a study of 1,051,032 23andMe research participants, we report …
[HTML][HTML] Associations between polygenic risk score and covid-19 susceptibility and severity across ethnic groups: UK Biobank analysis
R Farooqi, JS Kooner, W Zhang - BMC Medical Genomics, 2023 - Springer
Background COVID-19 manifests with huge heterogeneity in susceptibility and severity
outcomes. UK Black Asian and Minority Ethnic (BAME) groups have demonstrated …
outcomes. UK Black Asian and Minority Ethnic (BAME) groups have demonstrated …
Systematic review and meta-analysis of human genetic variants contributing to COVID-19 susceptibility and severity
K Gupta, G Kaur, T Pathak, I Banerjee - Gene, 2022 - Elsevier
The COVID-19 pandemic has spawned global health crisis of unprecedented magnitude,
claiming millions of lives and pushing healthcare systems in many countries to the brink …
claiming millions of lives and pushing healthcare systems in many countries to the brink …
[HTML][HTML] The human genetic epidemiology of COVID-19
Human genetics can inform the biology and epidemiology of coronavirus disease 2019
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …
[HTML][HTML] Estimating the strength of selection for new SARS-CoV-2 variants
Controlling the SARS-CoV-2 pandemic becomes increasingly challenging as the virus
adapts to human hosts through the continual emergence of more transmissible variants …
adapts to human hosts through the continual emergence of more transmissible variants …