DKK1 activates noncanonical NF-κB signaling via IL-6–induced CKAP4 receptor in multiple myeloma
X Li, J Wang, S Zhu, J Zheng, Y Xie, H Jiang… - Blood …, 2021 - ashpublications.org
Proteasome inhibitors, such as bortezomib (BTZ), represent the key elements in
chemotherapy regimens for multiple myeloma (MM), whereas acquired chemoresistance …
chemotherapy regimens for multiple myeloma (MM), whereas acquired chemoresistance …
DKK1 suppresses WWP2 to enhance bortezomib resistance in multiple myeloma via regulating GLI2 ubiquitination
Q Zhang, W Gong, H Wu, J Wang, Q Jin, C Lin… - …, 2021 - academic.oup.com
Bortezomib-based chemotherapy represents the most prevalent regimens for multiple
myeloma (MM), whereas acquired drug resistance remains a major obstacle. Myeloma cells …
myeloma (MM), whereas acquired drug resistance remains a major obstacle. Myeloma cells …
Differential expression of DKK-1 binding receptors on stromal cells and myeloma cells results in their distinct response to secreted DKK-1 in myeloma
X Dun, H Jiang, J Zou, J Shi, L Zhou, R Zhu, J Hou - Molecular cancer, 2010 - Springer
Abstract Background The canonical Wnt signaling is concurrently important for osteoblast
differentiation and myeloma cell proliferation. Its activation in myeloma cells and its inhibition …
differentiation and myeloma cell proliferation. Its activation in myeloma cells and its inhibition …
Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma
M Fulciniti, P Tassone, T Hideshima… - Blood, The Journal …, 2009 - ashpublications.org
Decreased activity of osteoblasts (OBs) contributes to osteolytic lesions in multiple myeloma
(MM). The production of the soluble Wnt inhibitor Dickkopf-1 (DKK1) by MM cells inhibits OB …
(MM). The production of the soluble Wnt inhibitor Dickkopf-1 (DKK1) by MM cells inhibits OB …
The oxidative stress response regulates DKK1 expression through the JNK signaling cascade in multiple myeloma plasma cells
S Colla, F Zhan, W Xiong, X Wu, H Xu, O Stephens… - Blood, 2007 - ashpublications.org
Multiple myeloma (MM) plasma cells, but not those from healthy donors and patients with
monoclonal gammopathy of undetermined significance or other plasma cell dyscrasias …
monoclonal gammopathy of undetermined significance or other plasma cell dyscrasias …
Dickkopf-1 is a key regulator of myeloma bone disease: opportunities and challenges for therapeutic intervention
F Zhou, S Meng, H Song, FX Claret - Blood reviews, 2013 - Elsevier
Myeloma bone disease (MBD) is the most visible aspect of plasma cell myeloma (PCM),
which is characterized by the displacement of hematopoiesis and the formation of osteolytic …
which is characterized by the displacement of hematopoiesis and the formation of osteolytic …
Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma
YW Qiang, B Barlogie, S Rudikoff, JD Shaughnessy Jr - Bone, 2008 - Elsevier
Expression of the Wnt signaling inhibitor, DKK1 by multiple myeloma cells is correlated with
lytic bone disease in multiple myeloma. However, the mechanism (s) by which DKK1 …
lytic bone disease in multiple myeloma. However, the mechanism (s) by which DKK1 …
[HTML][HTML] Inactivation of CK1α in multiple myeloma empowers drug cytotoxicity by affecting AKT and β-catenin survival signaling pathways
S Manni, M Carrino, M Manzoni, K Gianesin… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Recent evidence indicates that protein kinase CK1α may support the growth of multiple
myeloma (MM) plasma cells. Here, by analyzing a large cohort of MM cases, we found that …
myeloma (MM) plasma cells. Here, by analyzing a large cohort of MM cases, we found that …
Dickkopf-1: a suitable target for the management of myeloma bone disease
M Gavriatopoulou, MA Dimopoulos… - Expert opinion on …, 2009 - Taylor & Francis
Bone disease remains a major problem in the management of patients with multiple
myeloma (MM) and is characterized by the presence of lytic lesions due to increased …
myeloma (MM) and is characterized by the presence of lytic lesions due to increased …
Correlations of DKK1 with pathogenesis and prognosis of human multiple myeloma
Y Feng, Y Zhang, X Wei, Q Zhang - Cancer Biomarkers, 2019 - content.iospress.com
OBJECTIVE: Human multiple myeloma (MM) is a kind of common tumor in middle-aged and
elderly people, in which the osteolytic lesion is formed mainly through inhibiting osteoblast …
elderly people, in which the osteolytic lesion is formed mainly through inhibiting osteoblast …