The ADP-ribosyltransferase C3 exoenzyme from C. botulinum selectively inactivates Rho
and is therefore often used as an inhibitor for investigations on Rho signaling. Previous …

C3 exoenzyme from C. botulinum is an ADP-ribosyltransferase that inactivates selectively
RhoA, B, and C by coupling an ADP-ribose moiety. Rho-GTPases are involved in various …

rho p21 is a member of the ras superfamily of small GTPases. Clostridium botulinum C3
exoenzyme ADP-ribosylates rho p21 at the Asp41 residue located at an effector domain and …

Low‐molecular‐weight GTP‐binding proteins of the Rho family control the organization of
the actin cytoskeleton in eukaryotic cells. Dramatic reorganization of the actin cytoskeleton is …

GTP-BINDrNG proteins can be divided into three categories. The first is those involved in
protein synthesis such as elongation factors in ribosomes. The second is a group of …

Botulinum C3 exoenzyme was used to specifically ADP-ribosylate and inactivate rho p21,
and the effects of rho p21 inactivation on lysophosphatidic acid (LPA)-induced tyrosine …

C3 exoenzyme from Clostridium botulinum ADP-ribosylates the small GTP-binding protein
Rho with a high specificity. The use of C3 has shown that Rho-mediated signaling is …

Abstract Small Rho GTPases are key regulators of the cytoskeleton in a great variety of cells.
Rho function mediates morphological changes as well as locomotor activity. Using astrocyte …

The differential expression of Rho family of low molecular weight GTP-binding proteins and
protein kinase C (PKC) isozymes were examined during differentiation of rat C6 glial cells to …

Rho small GTPases regulate a variety of cellular signaling pathways involved in cell growth
and transformation. In this study, we examined potential roles for Rho in adhesion …