The concept of 'niche'has become a focus of attention in hematologic malignancies
including acute myeloid leukemia (AML). Similar to normal hematopoietic stem cells, AML …

The bone marrow microenvironment plays a critical role in the development, progression,
and relapse of acute myeloid leukemia (AML). Similar to normal hematopoietic stem cells …

Despite extensive research and development of new treatments, acute myeloid leukemia
(AML)-backbone therapy has remained essentially unchanged over the last decades and is …

Objectives: To summarize the effects of the bone marrow niche on hematopoiesis and
leukemogenesis and discuss the chemotherapy resistance that can arise from interactions …

The expansion of acute myeloid leukemia (AML) blasts not only suppresses normal
hematopoiesis, but also alters the microenvironment. The interplay of different components …

The interactions between the cancerous cells of acute myeloid leukemia (AML) and the
bone marrow (BM) microenvironment have been postulated to be important for resistance to …

A tight relationship between the acute myeloid leukemia (AML) population and the bone
marrow (BM) microenvironment has been convincingly established. The AML clone contains …

As part of the dynamic interactions between leukemic cells and cells of the bone marrow
microenvironment, specific niches provide a sanctuary where subpopulations of leukemic …

The chemokine receptor CXCR4 is critically involved in migration of hematopoietic cells to
the stromal derived factor (SDF-1α)-producing bone marrow microenvironment. CXCR4 is …

The bone marrow (BM) stromal niche can protect acute lymphoblastic leukemia (ALL) cells
against the cytotoxicity of chemotherapeutic agents and is a possible source of relapse. The …