Discovering novel changes in the proteome of malignant lung epithelial cells and/or the
tumor-microenvironment is paramount for diagnostic, prognostic, and/or therapy …

We used isobaric tag labeling coupled with mass spectrometry to compare the relative
abundance of proteins in lung tumors from A/J mice treated with a mixture of 4 …

The tobacco-specific N-nitrosamine, 4-(methylnitrosamino)-1-(3-pyridinyl)-1-butanone
(NNK), is a well-known carcinogen. Although the ability of the metabolically activated form of …

Abstract Purpose NNK [4-(methylnitrosamino)-1-(3-pyridyle)-1-butanone] is a nicotine-
derived nitrosaminoketone contained in tobacco smoke used as a powerful chemical …

We tested the chemopreventive efficacy of indole-3-carbinol (I3C), a constituent of Brassica
vegetables, and its major condensation product, 3, 3′-diindolylmethane (DIM), against lung …

We have previously shown that N-methyl-N′-nitro-N-nitrosoguanidine (MNNG), a well-
known DNA alkylating agent and carcinogen, can induce multiple cellular responses with …

Lung cancer remains the leading cause of cancer-related deaths worldwide. In order to
understand lung cancer biology and evaluate novel therapeutic strategies, preclinical …

We used a proteomics approach (iTRAQ) to identify differentially expressed lung proteins
during early stages of the tobacco carcinogen, NNK-induced lung tumorigenesis …

The incidence of lung adenocarcinoma has been remarkably increasing in recent years due
to the introduction of filter cigarettes and secondary‐hand smoking because the people are …

Alkylating agent MNNG (N-methyl-N '-nitro-N-nitrosoguanidine) can induce DNA damages
which can lead to chromosomal aberrations, mutations, and cell death. Previous reports …