Fibrosis of the glomerular and tubulointerstitial compartments is a common feature of chronic
kidney disease leading to end-stage renal failure. This fibrotic process involves a number of …

Renal fibrosis and tubular apoptosis are common mechanisms of progressive kidney
disease. In vitro studies have implicated the c-Jun amino-terminal kinase (JNK) pathway in …

Two major stress-activated protein kinases are the p38 mitogen-activated protein kinase
(MAPK) and the c-Jun amino terminal kinase (JNK). p38 and JNK are widely expressed in …

Renal fibrosis is the culmination of processes driven by signaling pathways involving
transforming growth factor-β family of cytokines, connective-tissue growth factor, nuclear …

Chronic kidney disease (CKD) is a major public health issue. At the histological level, renal
fibrosis is the final common pathway of progressive kidney disease irrespective of the initial …

Renal interstitial fibrosis is a common pathological feature in progressive kidney diseases
currently lacking effective treatment. Nicotinamide (NAM), a member of water‐soluble …

The renal tubules are the major component of the kidney and are vulnerable to a variety of
injuries including ischemia, proteinuria, toxins, and metabolic disorders. It has long been …

Fibrosis is responsible for chronic progressive kidney failure, which is present in a large
number of adults in the developed world. It is increasingly appreciated that acute kidney …

Acute kidney injury (AKI) is one of the main conditions responsible for chronic kidney
disease (CKD), including end-stage renal disease (ESRD) as a long-term complication …

Tubulointerstitial fibrosis is a common feature of many progressive renal diseases and is a
main determinant that leads to an irreversible loss of renal function. In chronic cyclosporinA …