[HTML][HTML] Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination

MM Painter, D Mathew, RR Goel, SA Apostolidis… - Immunity, 2021 - cell.com
SARS-CoV-2 mRNA vaccines have shown remarkable clinical efficacy, but questions
remain about the nature and kinetics of T cell priming. We performed longitudinal antigen …

[HTML][HTML] Booster dose of mRNA vaccine augments waning T cell and antibody responses against SARS-CoV-2

FG Özbay Kurt, A Lepper, C Gerhards… - Frontiers in …, 2022 - frontiersin.org
A gradual decay in humoral and cellular immune responses over time upon SAR1S-CoV-2
vaccination may cause a lack of protective immunity. We conducted a longitudinal analysis …

[HTML][HTML] Dynamics of spike-and nucleocapsid specific immunity during long-term follow-up and vaccination of SARS-CoV-2 convalescents

N Koerber, A Priller, S Yazici, T Bauer… - Nature …, 2022 - nature.com
Anti-viral immunity continuously declines over time after SARS-CoV-2 infection. Here, we
characterize the dynamics of anti-viral immunity during long-term follow-up and after …

[HTML][HTML] Immunodeficiency syndromes differentially impact the functional profile of SARS-CoV-2-specific T cells elicited by mRNA vaccination

Y Gao, C Cai, D Wullimann, J Niessl… - Immunity, 2022 - cell.com
Many immunocompromised patients mount suboptimal humoral immunity after SARS-CoV-2
mRNA vaccination. Here, we assessed the single-cell profile of SARS-CoV-2-specific T cells …

[HTML][HTML] Differential effects of the second SARS-CoV-2 mRNA vaccine dose on T cell immunity in naive and COVID-19 recovered individuals

D Lozano-Ojalvo, C Camara, E Lopez-Granados… - Cell reports, 2021 - cell.com
The rapid development of mRNA-based vaccines against the severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2) led to the design of accelerated vaccination …

[HTML][HTML] Cellular and humoral immune responses and breakthrough infections after three SARS-CoV-2 mRNA vaccine doses

P Almendro-Vázquez, M Chivite-Lacaba… - Frontiers in …, 2022 - frontiersin.org
Background SARS-CoV-2 vaccination has proven the most effective measure to control the
COVID-19 pandemic. Booster doses are being administered with limited knowledge on their …

[HTML][HTML] SARS-CoV-2 mRNA vaccine induces robust specific and cross-reactive IgG and unequal neutralizing antibodies in naive and previously infected people

TM Narowski, K Raphel, LE Adams, J Huang, NA Vielot… - Cell reports, 2022 - cell.com
Understanding vaccine-mediated protection against severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2) is critical to overcoming the global coronavirus disease 2019 …

[HTML][HTML] Single-cell profiling of T and B cell repertoires following SARS-CoV-2 mRNA vaccine

S Sureshchandra, SA Lewis, BM Doratt, A Jankeel… - JCI insight, 2021 - ncbi.nlm.nih.gov
Abstract mRNA vaccines for SARS-CoV-2 have shown exceptional clinical efficacy,
providing robust protection against severe disease. However, our understanding of …

Robust immune responses are observed after one dose of BNT162b2 mRNA vaccine dose in SARS-CoV-2–experienced individuals

MI Samanovic, AR Cornelius… - Science translational …, 2021 - science.org
The use of coronavirus disease 2019 (COVID-19) vaccines will play the major role in
helping to end the pandemic that has killed millions worldwide. COVID-19 vaccines have …

[HTML][HTML] A comparative characterization of SARS-CoV-2-specific T cells induced by mRNA or inactive virus COVID-19 vaccines

JME Lim, SK Hang, S Hariharaputran, A Chia… - Cell Reports …, 2022 - cell.com
Unlike mRNA vaccines based only on the spike protein, inactivated severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2) vaccines should induce a diversified T cell …