Colorectal cancer (CRC) is a heterogeneous disease of the intestinal epithelium that is
characterized by the accumulation of mutations and a dysregulated immune response. Up to …

Colorectal cancer (CRC) is a substantial source of global morbidity and mortality in dire
need of improved prevention and treatment strategies. As our understanding of CRC grows …

The importance of the microbiota in the development of colorectal cancer (CRC) is
increasingly evident, but identifying specific microbial features that influence CRC initiation …

BACKGROUND Historical accounts linking cancer and microbes date as early as four
millennia ago. After establishment of the germ theory of infectious diseases, clinical research …

Mounting evidence from metagenomic analyses suggests that a state of pathological
microbial imbalance or dysbiosis is prevalent in the gut of patients with colorectal cancer …

Colorectal cancer (CRC) is one of the most common cancers worldwide. As with other
cancers, CRC is a multifactorial disease due to the combined effect of genetic and …

Cancer arises from the acquisition of multiple genetic and epigenetic changes in host cells
over the span of many years, promoting oncogenic traits and carcinogenesis. Most cancers …

Multiple factors drive the progression from healthy mucosa towards sporadic colorectal
carcinomas and accumulating evidence associates intestinal bacteria with disease initiation …

Mechanisms of colorectal cancer (CRC) development can be generally divided into three
categories: genetic, epigenetic, and aberrant immunologic signaling pathways, all of which …

Colorectal cancer (CRC) is one of the commonest cancers globally. A unique aspect of CRC
is its intimate association with the gut microbiota, which forms an essential part of the tumour …