TRPV1 expressed throughout the arterial circulation regulates vasoconstriction and blood pressure
Key points The functional roles of the capsaicin receptor, TRPV1, outside of sensory nerves
are unclear. We mapped TRPV1 in the mouse circulation, revealing extensive expression in …
are unclear. We mapped TRPV1 in the mouse circulation, revealing extensive expression in …
TRPV channels and vascular function
RL Baylie, JE Brayden - Acta Physiologica, 2011 - Wiley Online Library
Transient receptor potential channels, of the vanilloid subtype (TRPV), act as sensory
mediators, being activated by endogenous ligands, heat, mechanical and osmotic stress …
mediators, being activated by endogenous ligands, heat, mechanical and osmotic stress …
TRPV1 in arteries enables a rapid myogenic tone
Arterioles maintain blow flow by adjusting their diameter in response to changes in local
blood pressure. In this process called the myogenic response, a vascular smooth muscle …
blood pressure. In this process called the myogenic response, a vascular smooth muscle …
Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells
The heat and capsaicin receptor, TRPV1, is required for the detection of painful heat by
primary afferent pain fibers (nociceptors), but the extent to which functional TRPV1 channels …
primary afferent pain fibers (nociceptors), but the extent to which functional TRPV1 channels …
Vascular smooth muscle TRPV4 (transient receptor potential vanilloid family member 4) channels regulate vasoconstriction and blood pressure in obesity
Y Zhu, Y Chu, S Wang, J Tang, H Li, L Feng, F Yu… - …, 2023 - Am Heart Assoc
Background: Vascular endothelium and smooth muscle work together to keep the balance of
vasomotor tone and jointly maintain vascular homeostasis. Ca2+-permeable ion channel …
vasomotor tone and jointly maintain vascular homeostasis. Ca2+-permeable ion channel …
The role of TRPV1 in improving VSMC function and attenuating hypertension
MJ Zhang, YW Yin, BH Li, Y Liu, SQ Liao… - Progress in biophysics …, 2015 - Elsevier
The transient receptor potential vanilloid type 1 (TRPV1) channel, a ligand-gated cation
channel of the TRP subfamily, can be activated by multiple stimuli, including capsaicin …
channel of the TRP subfamily, can be activated by multiple stimuli, including capsaicin …
Modulation of TRPV4 by diverse mechanisms
Transient receptor potential ion channels (TRP) are a superfamily of non-selective ion
channels which are opened in response to a diverse range of stimuli. The TRP vanilloid 4 …
channels which are opened in response to a diverse range of stimuli. The TRP vanilloid 4 …
TRPV4 and the regulation of vascular tone
Recent studies have introduced the importance of transient receptor potential vanilloid
subtype 4 (TRPV4) channels in the regulation of vascular tone. TRPV4 channels are …
subtype 4 (TRPV4) channels in the regulation of vascular tone. TRPV4 channels are …
Different desensitization patterns for sensory and vascular TRPV1 populations in the rat: expression, localization and functional consequences
Á Czikora, I Rutkai, ET Pásztor, A Szalai, R Pórszász… - PloS one, 2013 - journals.plos.org
Background and purpose TRPV1 is expressed in sensory neurons and vascular smooth
muscle cells, contributing to both pain perception and tissue blood distribution. Local …
muscle cells, contributing to both pain perception and tissue blood distribution. Local …
Capsaicin and TRPV1 channels in the cardiovascular system: the role of inflammation
Capsaicin is a potent agonist of the Transient Receptor Potential Vanilloid type 1 (TRPV1)
channel and is a common component found in the fruits of the genus Capsicum plants …
channel and is a common component found in the fruits of the genus Capsicum plants …