Organophosphorus compounds and MAPK signaling pathways
T Farkhondeh, O Mehrpour, C Buhrmann… - International journal of …, 2020 - mdpi.com
The molecular signaling pathways that lead to cell survival/death after exposure to
organophosphate compounds (OPCs) are not yet fully understood. Mitogen-activated …
organophosphate compounds (OPCs) are not yet fully understood. Mitogen-activated …
Tris (1, 3-dichloro-2-propyl) phosphate induces apoptosis and autophagy in SH-SY5Y cells: Involvement of ROS-mediated AMPK/mTOR/ULK1 pathways
Abstract Tris (1, 3-dichloro-2-propyl) phosphate (TDCIPP), an extensively used
organophosphorus flame retardant, is frequently detected in the environment and biota …
organophosphorus flame retardant, is frequently detected in the environment and biota …
Aryl-, halogenated-and alkyl-organophosphate esters induced oxidative stress, endoplasmic reticulum stress and NLRP3 inflammasome activation in HepG2 cells
Y Zhou, H Liao, S Yin, P Wang, X Ye, J Zhang - Environmental Pollution, 2023 - Elsevier
Organophosphate esters (OPEs) are a group of extensively used man-made chemicals with
diverse substituents that are ubiquitously detected in human-related samples including …
diverse substituents that are ubiquitously detected in human-related samples including …
Organophosphate flame retardants induce oxidative stress and Chop/Caspase 3-related apoptosis via Sod1/p53/Map3k6/Fkbp5 in NCI-1975 cells
Y Meng, X Xu, D Niu, Y Xu, Y Qiu, Z Zhu… - Science of the Total …, 2022 - Elsevier
Organophosphate flame retardants (OPFRs) have been ubiquitously detected in dust and air
which could cause damage to human health through inhalation. Currently the understanding …
which could cause damage to human health through inhalation. Currently the understanding …
Discovery of a benzofuran derivative (MBPTA) as a novel ROCK inhibitor that protects against MPP+-induced oxidative stress and cell death in SH-SY5Y cells
Parkinson disease (PD) is a neurodegenerative disease with multifactorial
etiopathogenesis. The discovery of drug candidates that act on new targets of PD is required …
etiopathogenesis. The discovery of drug candidates that act on new targets of PD is required …
High phosphate actively induces cytotoxicity by rewiring pro‐survival and pro‐apoptotic signaling networks in HEK293 and HeLa cells
P He, O Mann‐Collura, J Fling, N Edara… - The FASEB …, 2021 - Wiley Online Library
Inorganic phosphate (Pi) is an essential nutrient for human health. Due to the changes in our
dietary pattern, dietary Pi overload engenders systemic phosphotoxicity, including excessive …
dietary pattern, dietary Pi overload engenders systemic phosphotoxicity, including excessive …
[HTML][HTML] Transcriptomic, proteomic and metabolomic profiling unravel the mechanisms of hepatotoxicity pathway induced by triphenyl phosphate (TPP)
Triphenyl phosphate (TPP) has been found in various environmental media and in biota
suggesting widespread human exposure. However, there is still insufficient information on …
suggesting widespread human exposure. However, there is still insufficient information on …
JNK and p38 MAPK regulate oxidative stress and the inflammatory response in chlorpyrifos-induced apoptosis
YW Ki, JH Park, JE Lee, IC Shin, HC Koh - Toxicology letters, 2013 - Elsevier
To investigate mechanisms of neuronal cell death in response to chlorpyrifos (CPF), a
pesticide, we evaluated the regulation of ROS and COX-2 in human neuroblastoma SH …
pesticide, we evaluated the regulation of ROS and COX-2 in human neuroblastoma SH …
Impact of environmental toxicants on p38-and ERK-MAPK signaling pathways in the central nervous system
There are several candidate signalling pathways that mediate the response of the central
nervous system (CNS) cells to environmental toxins. However, much is still to be learned on …
nervous system (CNS) cells to environmental toxins. However, much is still to be learned on …
Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathway
L Chen, L Liu, J Yin, Y Luo, S Huang - … journal of biochemistry & cell biology, 2009 - Elsevier
Oxidative stress-induced neuronal apoptosis is a prominent feature found in
neurodegenerative disorders. However, how oxidative stress induces neuronal apoptosis is …
neurodegenerative disorders. However, how oxidative stress induces neuronal apoptosis is …