Cancer is a disease of ageing. Clinically, aged cancer patients tend to have a poorer
prognosis than young. This may be due to accumulated cellular damage, decreases in …

Disseminated cancer cells from primary tumours can seed in distal tissues, but may take
several years to form overt metastases, a phenomenon that is termed tumour dormancy …

Cellular senescence is a stress-responsive cell-cycle arrest program that terminates the
further expansion of (pre-) malignant cells,. Key signalling components of the senescence …

The process of metastasis is complex. In breast cancer, there are frequently long time
intervals between cells leaving the primary tumour and growth of overt metastases …

Aberrant activation of oncogenes or loss of tumour suppressor genes opposes malignant
transformation by triggering a stable arrest in cell growth, which is termed cellular …

Cellular senescence involves a stable cell-cycle arrest coupled to a secretory program that,
in some instances, stimulates the immune clearance of senescent cells. Using an immune …

Cellular senescence has been recently shown to have an important role in opposing tumour
initiation and promotion. Senescence induced by oncogenes or by loss of tumour …

Cancer-associated systemic inflammation is strongly linked to poor disease outcome in
patients with cancer,. For most human epithelial tumour types, high systemic neutrophil-to …

We have previously shown that W nt5 A drives invasion in melanoma. We have also shown
that W nt5 A promotes resistance to therapy designed to target the BRAF V600E mutation in …

Metastatic melanoma is an aggressive disease, despite recent improvements in therapy.
Eradicating all melanoma cells even in drug-sensitive tumors is unsuccessful in patients …