The L-type amino acid transporter (LAT) family are Na+-independent transporters, which
deliver neutral amino acids into cells. The four LATs, LAT1 (SLC7A5), LAT2 (SLC7A8), LAT3 …

The progression of cancer is associated with increases in amino acid uptake by cancer cells.
Upon their entry into cells through specific transporters, exogenous amino acids are used to …

L-type amino acid transporter 1 (LAT1) is an L-type amino acid transporter and transports
large neutral amino acids such as leucine, isoleucine, valine, phenylalanine, tyrosine …

Cancer cells require a massive supply of nutrients, including sugars and amino acids—the
upregulation of transporters for each nutrient contributes to meet the demand. Distinct from …

Tumor cells take up a massive amount of nutrition compared to normal cells for increased
metabolism. Therefore, special transporters for organic materials are required to satisfy the …

Chronic proliferation is a major hallmark of tumor cells. Rapidly proliferating cancer cells are
highly dependent on nutrients in order to duplicate their cell mass during each cell division …

L-type amino acid transporters (LATs) mainly assist the uptake of neutral amino acids into
cells. Four LATs (LAT1, LAT2, LAT3 and LAT4) have so far been identified. LAT1 (SLC7A5) …

Background The L-type amino acid transporter 1 (LAT1/SLC7A5) transports essential amino
acids across the plasma membrane. While LAT1 is overexpressed in a variety of human …

Amino acids, especially leucine and glutamine, are important for tumor cell growth, survival
and metabolism. A range of different transporters deliver each specific amino acid into cells …

The altered metabolism of cancer cells is a treasure trove to discover new antitumoral
strategies. The gene (SLC7A5) encoding system L amino-acid transporter 1 (LAT1) is …