Ceramide, generated by the action of acid sphingomyelinase (ASM), has emerged as a
biochemical mediator of stimuli as diverse as ionizing radiation, chemotherapy, UVA light …

Recent evidence suggests clustering of plasma membrane rafts into ceramide-enriched
platforms serves as a transmembrane signaling mechanism for a subset of cell surface …

In the last 30 years, ceramides have been found to mediate a myriad of biological
processes. Ceramides have been recognized as bioactive molecules and their metabolizing …

Acid sphingomyelinase (ASM) has been shown to be activated by a variety of receptor
molecules and stimuli including CD95, the tumor necrosis factor receptor (TNF-R), CD40 …

Cellular activation involves the re-organization of receptor molecules and the intracellular
signalosom in the cell membrane. Recent studies indicate that specialized domains of the …

Intensive research over the past 2 decades has implicated ceramide in the regulation of
several cell responses. However, emerging evidence points to dramatic complexities in …

Most of the previous work on the sphingolipid ceramide has been devoted to its function as
an apoptosis inducer. Recent studies, however, have shown that in stem cells, ceramide has …

Formerly considered to serve only as structural components, sphingolipids are emerging as
an important group of signaling molecules involved in many cellular events, including cell …

Ceramides have been implied in intracellular signal transduction systems regulating cellular
differentiation, activation, survival and apoptosis and thus appear capable of changing the …

Our understanding of the functions of ceramide signaling has advanced tremendously over
the past decade. In this review, we focus on the roles and regulation of neutral …