Small double-strand RNA (dsRNA) molecules can activate endogenous genes via an RNA-
based promoter targeting mechanism. RNA activation (RNAa) is an evolutionarily conserved …

Small activating RNAs (saRNAs) are small double-stranded RNAs that could mediate the
target-specific gene expression by targeting selected sequences in gene promoters at both …

Vector-based systems comprised of exogenous nucleic acid sequences remain the standard
for ectopic expression of a particular gene. Such systems offer robust overexpression, but …

RNA activation (RNAa) allows specific gene upregulation mediated by a small activating
RNA (saRNA). Harnessing this process would help in developing novel therapeutics for …

In recent years, RNA interference (RNAi) has become a tool of choice to analyze and target
the in vitro and in vivo function of mammalian genes. RNAi down-regulates gene expression …

Recent advancements in small RNA sequencing have unveiled a previously hidden world of
regulatory small noncoding RNAs (sncRNAs) that extend beyond the well-studied small …

Background RNA activation (RNAa) is a newly discovered mechanism of gene activation
triggered by small double-stranded RNAs termed 'small activating RNAs'(saRNAs). Thus far …

Small RNA molecules, such as microRNA and small interfering RNA, have emerged as
master regulators of gene expression through their ability to suppress target genes in a …

RNA interference (RNAi) is an evolutionary conserved mechanism by which small double-
stranded RNA (dsRNA)—termed small interfering RNA (siRNA)—inhibit translation or …

RNA activation (RNAa) is a novel mechanism in which short RNA duplexes, referred to as
small activating RNAs (saRNAs), enable sequence-specific gene activation capable of …